PMID: 8964765Mar 1, 1996Paper

Muscle O2 uptake kinetics in humans: implications for metabolic control

Journal of Applied Physiology
B GrassiP D Wagner

Abstract

Muscle O2 uptake (VO2) kinetics in response to an augmented energetic requirement (on-transition) has never been directly determined in humans. We have developed a constant-infusion thermodilution technique that allowed rapid measurements of leg blood flow (Qleg) and, in conjunction with frequent serial measurement of arteriovenous O2 content difference across the leg [(Ca - Cv)O2leg], permitted the determination of the VO2 of the leg (VO2leg) at 3- to 4-s time intervals. VO2leg kinetics during the on-transition was taken as a close approximation of muscle VO2 (VO2mus) kinetics. Alveolar VO2 (VO2A), Qleg, leg O2 delivery [(Q.CaO2leg)], (Ca - Cv)O2leg, and VO2leg kinetics were determined in six trained subjects [age 22.8 +/- 4.4 (SD) yr; maximal O2 uptake 59.1 +/- 5.3 ml.kg-1.min-1] during the transition from unloaded pedaling to a workload (loaded pedaling; LP) (183 +/- 20 W) well below the previously determined ventilatory threshold. For all variables, two distinct phases were recognized. During the first 10-15 s of loaded pedaling (phase I), VO2A, Qleg, and (Q.CaO2)leg increased rapidly, whereas VO2leg increased only slightly and (Ca - Cv)O2leg actually decreased. After phase I, all variables showed a monoexponential increase...Continue Reading

Citations

Dec 1, 1996·Journal of Applied Physiology·M EngelenT J Barstow
Oct 7, 1998·Journal of Applied Physiology·B W ScheuermannD A Cunningham
Nov 24, 1999·The American Journal of Physiology·N HayashiT Yoshida
Apr 1, 2000·Clinical and Experimental Pharmacology & Physiology·M Hargreaves
Apr 12, 2000·Acta Physiologica Scandinavica·M G ClarkJ M Newman
Oct 29, 2000·Journal of Applied Physiology·H CarterJ H Doust
May 17, 2002·Journal of Applied Physiology·Yoshiyuki FukubaTakayoshi Yoshida
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Bradley J BehnkeWilliam L Sexton
Aug 7, 2002·High Altitude Medicine & Biology·Benjamin D Levine
Mar 4, 2003·Journal of Applied Physiology·Bruno GrassiPaolo Cerretelli
Apr 8, 2003·Journal of Applied Physiology·Darren S DeLoreyDonald H Paterson
Dec 6, 2003·Journal of Applied Physiology·Andrew M JonesIain T Campbell
Feb 10, 2004·Medicine and Science in Sports and Exercise·Katrien KoppoAndrew M Jones
Jul 6, 2004·Clinical Physiology and Functional Imaging·Aurélien Bringard, Stéphane Perrey
Aug 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shunsaku KogaThomas J Barstow
Jan 11, 2005·Journal of Applied Physiology·Leonardo F FerreiraThomas J Barstow
Oct 23, 2004·The Journal of Physiology·James A TimmonsPaul L Greenhaff
May 24, 2005·Experimental Physiology·Leonardo F FerreiraThomas J Barstow
Apr 6, 2005·Medicine and Science in Sports and Exercise·Katrien Koppo, Jacques Bouckaert
Sep 24, 2005·Medicine and Science in Sports and Exercise·David C PooleDanielle J Padilla
Nov 17, 2005·Journal of Applied Physiology·Graham Kemp
Jun 3, 2006·Research Quarterly for Exercise and Sport·Krista G AustinEmily M Haymes
Sep 22, 2007·Journal of Applied Physiology·Shunsaku KogaThomas J Barstow
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·H J GreenA R Tupling
Nov 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B J GurdJ M Kowalchuk
Jun 1, 2003·Nutrition Research Reviews·Bettina Mittendorfer, Samuel Klein
Aug 8, 2009·Journal of Applied Physiology·Pietro Enrico di PramperoBruno Grassi
Dec 25, 2009·European Journal of Applied Physiology·Tyler A Churchward-VenneGreg D Marsh
Mar 3, 2010·European Journal of Applied Physiology·Carlo CapelliSilvia Pogliaghi
May 29, 2010·Journal of Applied Physiology·Dimitris AthanasopoulosIoannis Vogiatzis

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