Jan 4, 2008

Muscle phosphocreatine and pulmonary oxygen uptake kinetics in children at the onset and offset of moderate intensity exercise

European Journal of Applied Physiology
Alan BarkerNeil Armstrong


To further understand the mechanism(s) explaining the faster pulmonary oxygen uptake (p(VO)(2)) kinetics found in children compared to adults, this study examined whether the phase II p(VO)(2) kinetics in children are mechanistically linked to the dynamics of intramuscular PCr, which is known to play a principal role in controlling mitochondrial oxidative phosphorylation during metabolic transitions. On separate days, 18 children completed repeated bouts of moderate intensity constant work-rate exercise for determination of (1) PCr changes every 6 s during prone quadriceps exercise using (31)P-magnetic resonance spectroscopy, and (2) breath by breath changes in p(VO)(2) during upright cycle ergometry. Only subjects (n = 12) with 95% confidence intervals <or=+/-7 s for all estimated time constants were considered for analysis. No differences were found between the PCr and phase II p(VO)(2) time constants at the onset (PCr 23 +/- 5 vs. p(VO)(2) 23 +/- 4 s, P = 1.000) or offset (PCr 28 +/- 5 vs. p(VO)(2) 29 +/- 5 s, P = 1.000) of exercise. The average difference between the PCr and phase II p(VO)(2) time constants was 4 +/- 4 s for the onset and offset responses. Pooling of the exercise onset and offset responses revealed a signif...Continue Reading

Mentioned in this Paper

Metabolic Process, Cellular
Exercise, Isometric
Phosphate Measurement
Structure of Vastus Medialis Muscle

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