PMID: 5914758Oct 14, 1966

Muscle postjunctional membrane: changes in chemosensitivity produced by calcium

W L Nastuk, J H Liu


Increases in the extracellular concentration of calcium ions above 1.8 millimoles per liter caused a reversible decrease in the sensitivity of tmuscle postiunctional membrane to carbamylcholine. A quantitative study of the inhibitory effect of calcium ions on membrane depolarization produced by carbamylcholine indicates that calcium ions compete with carbamylcholine for some common binding sites on the postjunctional membrane. Calcium ions (20 millimoles per liter) caused a neuromuscular block wherein prolonged end plate potentials were produced after nerve stimulation. Calcium ions applied ionophoretically to the postjunctional membrane decreased the amplitude and prolonged the time course of the transient depolarization produced by ionophoretically applied carbamylcholine.


May 17, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·E G Henderson, L Reynolds
Sep 1, 1979·Biulleten' eksperimental'noĭ biologii i meditsiny·A A PolgarV P Fisenko
Sep 23, 1977·Biochemical and Biophysical Research Communications·M MihovilovicM Martinez-Carrion
Feb 1, 1976·Life Sciences·M KannoX Machne
Apr 1, 1972·Comparative Biochemistry and Physiology. A, Comparative Physiology·C L Ortiz, H Bracho
Sep 1, 1970·The Journal of General Physiology·D H Lambert, R L Parsons
Jun 1, 1974·British Journal of Pharmacology·K KostialB Slat
Sep 15, 1971·Annals of the New York Academy of Sciences·W L Nastuk
Jun 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·H RaduR Robu

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