Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel

Journal of Applied Physiology
Jianhua LiLawrence I Sinoway

Abstract

Reflex cardiovascular responses to muscle contraction are mediated by mechanical and metabolic stimulation of thin muscle afferent fibers. Metabolic stimulants and receptors involved in responses are uncertain. Capsaicin depolarizes thin sensory afferent nerves that have vanilloid type 1 receptors (VR1). Among potential endogenous ligands of thin fibers, H+ has been suggested as a metabolite mediating the reflex muscle response as well as a potential stimulant of VR1. It has also been suggested that acid-sensing ion channels (ASIC) mediate H+, evoking afferent nerve excitation. We have examined the roles of VR1 and ASIC in mediating cardiovascular reflex responses to acid stimulation of muscle afferents in a rat model. In anesthetized rats, injections of capsaicin into the arterial blood supply of triceps surae muscles evoked a biphasic response (n = 6). An initial fall in mean arterial pressure (from baseline of 95.8 +/- 9.5 to 70.4 +/- 4.5 mmHg, P < 0.05 vs. baseline) was followed by an increase (to 131.6 +/- 11.3 mmHg, P < 0.05 vs. baseline). Anandamide (an endogenous substance that activates VR1) induced the same change in blood pressure as did capsaicin. The pressor (but not depressor) component of the response was blocked...Continue Reading

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Citations

Oct 31, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mamta Gautam, Christopher J Benson
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jihong XingJianhua Li
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Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Jihong XingJianhua Li
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