Muscle protein metabolism in finishing pigs fed ractopamine.

Journal of Animal Science
W G BergenD B Anderson

Abstract

Forty crossbred barrows (average initial weight, 66.4 kg) were utilized to determine the effects of ractopamine (a phenethanolamine/beta adrenergic agonist) on protein accretion and synthesis, activities of cathepsins B, H, L and calcium-dependent proteinase and nucleic acid content of semitendinosus muscle (ST). All pigs were offered a 16% protein, mineral and vitamin fortified corn-soybean meal diet supplemented with either 0 or 20 ppm ractopamine for 14, 21, 28, 35 or 42 d. Protein synthesis (fractional rates) was studied in pigs at d 21 and 35; ST protease activities, protein and nucleic acid content were measured on d 14, 28 and 42. Ractopamine increased (P less than .01) ST total protein content and maintained RNA muscle concentration and total ST muscle RNA content. DNA content (mg/g ST) declined (P less than .05) upon ractopamine feeding, but total DNA per muscle remained unchanged except for d 42, when the ST muscles were largest. Fractional accretion rates (FAR) were 1.0 and 1.2% for control and ractopamine-fed pigs, respectively. Fractional protein synthesis rate (FSR) was higher (P less than .06) in ractopamine-fed pigs (6.1%/d) than in control pigs (4.4%/d). Fractional protein synthesis rate could account for the o...Continue Reading

Citations

Sep 6, 2007·Journal of Animal Science·W G Bergen
Jan 1, 2009·Animal : an International Journal of Animal Bioscience·A D Mitchell
Oct 19, 2016·Journal of Labelled Compounds & Radiopharmaceuticals·Kai SunYi Xu
Nov 7, 2017·Journal of Animal Science·C S MarcollaA Saraiva
Jul 17, 2013·Experimental Biology and Medicine·Michael V DodsonGary J Hausman
Jun 16, 2016·Experimental Biology and Medicine·Werner G Bergen, Terry D Brandebourg
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·Bradley J JohnsonKi Yong Chung
Feb 1, 2018·Journal of Animal Science·Gary J HausmanSteve B Smith
Mar 21, 1998·The Journal of Nutrition·A W BellR J Harrell

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