PMID: 108362Apr 1, 1979

Muscle satellite cells in malnourished and nutritionally rehabilitated children

Journal of the Neurological Sciences
F M Hansen-SmithM H Golden

Abstract

Satellite cells were examined qualitatively and quantitatively in muscle biopsies from children when malnourished, during nutritional rehabilitation, and after clinical recovery. The proportion of satellite cell nuclei relative to myonuclei was significantly lower in malnourished subjects than in well-nourished age-matched controls (4.5 +/- 1% vs. 8.1 +/- 1.0%). The proportion of satellite cells remained low during the early period of "catch-up growth" but was significantly increased in the recovered subjects (10.5 +/- 1.0%). Satellite cells were small and their nuclei were heterochromatic in biopsies from the malnourished subjects. The cells were often partially segregated from the parent fiber by an external lamina. In recovering and recovered subjects many of the satellite cells enlarged, and the appearance of their nuclei and cytoplasmic organelles suggested a more active state. Intervention of external lamina between the satellite cell and the myofibre was uncommon in the recovered subjects.

References

Mar 1, 1979·The British Journal of Nutrition·F M Hansen-SmithM H Golden
Jul 1, 1976·The Anatomical Record·H Schmalbruch, U Hellhammer
Sep 1, 1976·Journal of Neuropathology and Experimental Neurology·Y Wakayama
Sep 1, 1976·The American Journal of Anatomy·E Schultz
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·H Teräväinen
Dec 1, 1974·The Anatomical Record·R Bischoff
Aug 1, 1971·The Anatomical Record·F P Moss, C P Leblond
Jun 1, 1968·The Journal of Pediatrics·B L NicholsD J Barnes
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·A MAURO
Nov 1, 1962·Journal of Clinical Pathology·R D Montgomery

Citations

Jan 21, 2011·Stem Cells and Development·Melissa WooMary Elizabeth Patti
Jan 11, 2013·Physiological Reviews·Hang YinMichael A Rudnicki

Related Concepts

Age Factors
Cell Density
DNA, Double-Stranded
Electron Microscopy
Muscle
Marasmus
RNA

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