Muscle strength and ageing: methodological aspects of isokinetic dynamometry and androgen administration

Clinical and Experimental Pharmacology & Physiology
Lam P Ly, David J Handelsman

Abstract

1. To evaluate interventions aiming to increase muscle strength in older men, it is necessary to use an objective and reproducible method to measure strength. The most reliable method to evaluate muscle strength is isokinetic peak torque (PT) measured by a dynamometer; however, raw PT varies with differences in body size and an optimal scaling for body physique to control confounding effects of body size is necessary to make the most valid comparisons. 2. The present study was designed to estimate the effects of age (part A) and androgen administration (part B) on muscle strength and to estimate reproducibility and evaluate various scaling methods in order to optimize comparisons of isokinetic PT measurements. 3. A single isokinetic exercise protocol was used to compare the muscle strength of 31 healthy men of two age groups (< 40 and > 60 years; part A) and change in strength due to administration of dihydrotestosterone (DHT; 70 mg/day) or placebo gel for 3 months in 35 healthy older (> or = 60 years) men (part B). 4. Muscle strength was assessed by a total of 16 PT measurements using a Cybex NORM dynamometer (Cybex, Ronkonkoma, NY, USA). Age-related differences in muscle strength were estimated by using PT evaluated as raw da...Continue Reading

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Jul 19, 2006·European Journal of Applied Physiology·Mark C PerryDi J Newham
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Dec 1, 2010·Hormone Molecular Biology and Clinical Investigation·Farid Saad

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