Muscle strength and fatigue in newly diagnosed patients with myasthenia gravis

Muscle & Nerve
Lotte Vinge, Henning Andersen

Abstract

Dynamometry is increasingly used as an objective measurement of muscle strength in neurological diseases. No study has applied dynamometry in untreated newly diagnosed patients with myasthenia gravis (MG). Isometric muscle strength at the shoulder, knee, and ankle was determined in 21 MG patients before and after initial anti-myasthenic treatment. Isometric strength was compared with MG evaluation scales. Muscle strength was reduced for knee extensors and shoulder abductors but normal for ankle extensors. Isometric muscle strength did not correlate significantly with manual muscle testing (MG Composite). Dynamometry revealed improved muscle strength of up to 50% (median 17%; range -1.8-49.8) despite no change in the MG Composite score. Dynamometry appears to be a more sensitive method of identifying changes in limb strength than MG evaluation scales. This supports the use of dynamometry in MG patients, especially for evaluation of the effect of anti-myasthenic treatment. Muscle Nerve 54: 709-714, 2016.

References

Jul 21, 1998·Annals of the New York Academy of Sciences·R J BarohnW W Bryan
May 5, 1999·Neurology·G I WolfeR J Barohn
Jul 11, 2001·Lancet·A VincentD Hilton-Jones
Mar 30, 2002·East African Medical Journal·W B MatujaE M Mgaya
Jul 13, 2002·Muscle & Nerve·Brian L Allman, Charles L Rice
Nov 1, 2003·Annals of the New York Academy of Sciences·Donald B SandersJanice M Massey
Jul 22, 2008·Muscle & Nerve·Ted M BurnsUNKNOWN Muscle Study Group
Nov 20, 2008·Muscle & Nerve·Ted M BurnsUNKNOWN Muscle Study Group
Apr 21, 2009·Lancet Neurology·Matthew N Meriggioli, Donald B Sanders
Oct 9, 2009·Muscle & Nerve·Caitlin J SymonetteTimothy J Doherty
Feb 5, 2010·Neuroepidemiology·Anita McGroganCorinne S de Vries
May 5, 2010·Neurology·Ted M BurnsUNKNOWN MG Composite and MG-QOL15 Study Group
Jun 29, 2010·Muscle & Nerve·Ted M Burns
Sep 9, 2010·Scandinavian Journal of Public Health·Lise G AndersenMette Aadahl
May 10, 2011·Medicine and Science in Sports and Exercise·Katharina E SchnackenburgSteven K Boyd
May 9, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Tom BroekmansPeter Feys
Aug 14, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E G PedersenD Gaist
Jan 9, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L H MarkvardsenUNKNOWN Danish CIDP and MMN Study Group
Oct 15, 2013·Acta Neurologica Scandinavica·S Cejvanovic, J Vissing
Jul 2, 2014·Acta Neurologica Scandinavica·P Joensen
Apr 29, 2015·Muscle & Nerve·Julie S HansenHenning Andersen

❮ Previous
Next ❯

Citations

Jan 14, 2017·Muscle & Nerve·Martin Amadeus RahbekUlrik Dalgas
Oct 14, 2017·Nature Reviews. Neurology·Iris-Katharina Penner, Friedemann Paul
Aug 21, 2016·Muscle & Nerve·Berit JordanStephan Zierz
Apr 26, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y GuanM Li
May 27, 2021·Muscle & Nerve·Jan L S ThomsenHenning Andersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.