Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease

Journal of Pediatric Hematology/oncology
Kelly A DoughertyVirginia A Stallings


In African-American children aged 5 to 17 years with and without type SS sickle cell disease (SCD-SS), dominant hand maximal handgrip strength, peak power, and plantar flexion isometric maximal voluntary contraction (MVC) torque were compared with adjustments for body size and composition. Children with SCD-SS (n=21; age, 11±1 y) compared with healthy control children (n=23; 10±1 y) did not differ by age, sex, or maturation stage, but had significantly lower Z scores for height, weight, body mass index, arm circumference, upper arm muscle area, and lean mass-for-height. Children with SCD-SS had significantly lower unadjusted handgrip strength (16±2 vs. 23±2 kg, P<0.01), peak power (1054±107 vs. 1488±169 W, P<0.04) and MVC torques at 2 angles (10 degrees: 27±3 vs. 42±5 Nm; 20 degrees: 21±3 vs. 34±4 Nm; all P<0.05). Performance decrements persisted when handgrip strength was adjusted for lean body mass and fat mass explaining 66% of the variance; peak power adjusted for age, lean body mass, fat mass, and height explaining 91% of the variance; and the highest MVC torque (10-degree angle) adjusted for left leg length, lean mass-for-height, and fat mass-for-height Z scores explaining 65% of the variance. This suggests additional fac...Continue Reading


Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Apr 1, 1971·Archives of Disease in Childhood·C G Brook
Feb 1, 1983·The American Journal of Cardiology·W CovitzR H DuRant
Nov 1, 1981·The American Journal of Clinical Nutrition·A R Frisancho
Apr 1, 1981·American Journal of Diseases of Children·B S AlpertT Hayashidera
Jan 1, 1996·Journal of Shoulder and Elbow Surgery·B G LegginE C Thompson
Jun 26, 2002·The American Journal of Clinical Nutrition·Elizabeth M BardenBabette S Zemel
Dec 25, 2004·British Journal of Sports Medicine·H McKayK M Khan
Dec 20, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Sarah R PearsonW Thomas Boyce
Sep 21, 2006·American Journal of Hematology·Hisham MoheebMahmoud S El-Sayed
Jun 29, 2007·Medicine and Science in Sports and Exercise·Hechmi ToumiJohn Fairclough
May 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E E OkuyucuS Yilmazer
Mar 17, 2010·Muscle & Nerve·Chandramouli Krishnan, Glenn N Williams
Apr 2, 2010·American Journal of Preventive Medicine·Kathryn L Hassell
Jan 14, 2011·Journal of Pediatric Hematology/oncology·Kelly A DoughertyBabette S Zemel
Aug 27, 2011·Autonomic Neuroscience : Basic & Clinical·Wolney de Andrade MartinsCharles Mady
May 25, 2012·Annals of Human Biology·Bethany J FosterBabette S Zemel
Jun 5, 2012·Experimental Physiology·Veline S L'EsperanceGeraldine F Clough
Jun 1, 1980·Journal of Youth and Adolescence·N M Morris, J R Udry
Jan 24, 2014·American Journal of Physiology. Cell Physiology·Cassandra R Nelson, Robert H Fitts
Dec 6, 2014·The Journal of Pediatrics·Anthony M AlvaradoRobert I Liem
Mar 17, 2015·The American Journal of Pathology·Marion RavelojaonaLaurent A Messonnier
May 20, 2015·Journal of Pediatric Hematology/oncology·Kelly A DoughertyVirginia A Stallings
Jun 20, 2015·Journal of Nutritional Science·Patrice L CapersJacqueline M Hibbert
Jul 22, 2015·Journal of Strength and Conditioning Research·Frank M PernaWilliam J Kraemer
Jan 23, 2017·Blood Cells, Molecules & Diseases·Benjamin ChatelDavid Bendahan


Nov 26, 2019·Family & Community Health·Cynthia W KarlsonMichael A Welsch
Nov 26, 2019·Journal of Pediatric Hematology/oncology·Jefferson N BrownellVirginia A Stallings
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Samah Attia El ShemyHanan Ali Madani
Aug 21, 2019·Oxidative Medicine and Cellular Longevity·Etienne GouraudCamille Faes
Feb 12, 2021·Cardiology in the Young·Catherine M AvitabileBabette S Zemel
Aug 11, 2018·Medicine and Science in Sports and Exercise·Angèle N MerletLaurent A Messonnier

Related Concepts

Age Factors
Anemia, Sickle Cell
Nutritional Status
Hand Strength
Anemia, Sickle Cell
Kidney Failure, Chronic
African American

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