Muscle structural, energetic and functional benefits of endurance exercise training in sickle cell disease
Abstract
Sickle cell disease (SCD) patients display skeletal muscle hypotrophy, altered oxidative capacity, exercise intolerance and poor quality of life. We previously demonstrated that moderate-intensity endurance training is beneficial for improving muscle function and quality of life of patients. The present study evaluated the effects of this moderate-intensity endurance training program on skeletal muscle structural and metabolic properties. Of the 40 randomized SCD patients, complete data sets were obtained from 33. The training group (n=15) followed a personalized moderate-intensity endurance training program, while the non-training (n=18) group maintained a normal lifestyle. Biopsies of the vastus lateralis muscle and submaximal incremental cycling tests were performed before and after the training program. Endurance training increased type I muscle fiber surface area (p=0.038), oxidative enzyme activity [citrate synthase, p<0.001; β-hydroxyacyl-CoA dehydrogenase, p=0.009; type-I fiber cytochrome c oxidase, p=0.042; respiratory chain complex IV, p=0.017] and contents of respiratory chain complexes I (p=0.049), III (p=0.005), IV (p=0.003) and V (p=0.002). Respiratory frequency, respiratory exchange ratio, blood lactate concentra...Continue Reading
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References
Evidence for a profound remodeling of skeletal muscle and its microvasculature in sickle cell anemia
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
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