Muscle structural, energetic and functional benefits of endurance exercise training in sickle cell disease

American Journal of Hematology
Angèle N MerletEXDRE collaborative study group


Sickle cell disease (SCD) patients display skeletal muscle hypotrophy, altered oxidative capacity, exercise intolerance and poor quality of life. We previously demonstrated that moderate-intensity endurance training is beneficial for improving muscle function and quality of life of patients. The present study evaluated the effects of this moderate-intensity endurance training program on skeletal muscle structural and metabolic properties. Of the 40 randomized SCD patients, complete data sets were obtained from 33. The training group (n=15) followed a personalized moderate-intensity endurance training program, while the non-training (n=18) group maintained a normal lifestyle. Biopsies of the vastus lateralis muscle and submaximal incremental cycling tests were performed before and after the training program. Endurance training increased type I muscle fiber surface area (p=0.038), oxidative enzyme activity [citrate synthase, p<0.001; β-hydroxyacyl-CoA dehydrogenase, p=0.009; type-I fiber cytochrome c oxidase, p=0.042; respiratory chain complex IV, p=0.017] and contents of respiratory chain complexes I (p=0.049), III (p=0.005), IV (p=0.003) and V (p=0.002). Respiratory frequency, respiratory exchange ratio, blood lactate concentra...Continue Reading


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Related Concepts

3-Hydroxyacyl CoA Dehydrogenases
Anemia, Sickle Cell
Citrate (si)-Synthase
Clinical Trials
Cytochrome C Oxidase
Laboratory Procedures

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