Muscle sympathetic nerve activity and ventilation during exercise in subjects with and without chronic heart failure.

The Canadian Journal of Cardiology
Klaus K A WitteJ S Floras

Abstract

Changes within skeletal muscle, including augmentation of its capacity to elicit reflex increases in both efferent muscle sympathetic nerve activity (MSNA) and ventilation during work, contribute significantly to exercise intolerance in heart failure (HF). Previously, we demonstrated that peak oxygen uptake (pVO(2)) in HF relates inversely to MSNA at rest and during exercise. To test the hypothesis that there is an independent positive relationship between resting MSNA and the ratio of ventilation to carbon dioxide output during exercise (VE/VCO(2)) that is augmented in HF. MSNA at rest and VE/VCO(2)) during stationary cycling were measured in 30 patients (27 men) with HF (mean +/- SD ejection fraction 20+/-6%) and in 31 age-matched controls (29 men). MSNA was higher in HF patients than in controls (51.5+/-14.3 bursts/min versus 33.0+/-11.1 bursts/min; P<0.0001). The VE/VCO(2) slope was also higher in HF patients than in controls (33.7+/-5.7 versus 26.0+/-3.5; P<0.0001), whereas pVO(2) was lower in HF patients than in controls (18.6+/-6.6 versus 31.4+/-8.4 mL/kg/min; P<0.0001). There were significant relationships between MSNA and VE/VCO(2) in both HF (r=0.50; P=0.005) and control subjects (r=0.36; P=0.046). The slope of this r...Continue Reading

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Citations

Jan 25, 2011·American Journal of Respiratory and Critical Care Medicine·Darryl Y Sue
Aug 11, 2012·Wiener klinische Wochenschrift·Wilhelm GranderMartin W Dünser
Jul 22, 2009·Respiratory Medicine·Tobias RaupachStefan Andreas
Oct 28, 2014·Physiological Reports·Keisho KatayamaShigehiko Ogoh
Sep 29, 2015·Medicine and Science in Sports and Exercise·Erik H Van ItersonThomas P Olson

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