Muscle sympathetic nerve activity in patients with Chagas' disease

International Journal of Cardiology
Carlos E NegrãoHolly R Middlekauff

Abstract

The progression of heart failure in Chagas' disease has been explained by remodeling, leading to neurohumoral activation, or by the direct parasite damage to parasympathetic neurons during acute phase, leading to early sympathetic activation and progressive heart failure. To help distinguish between these hypotheses we studied muscle sympathetic nerve activity (MSNA) at rest and during handgrip exercise (30% of maximal voluntary contraction) in patients with Chagas' disease and normal ejection fraction vs. patients with heart failure. A consecutive study of 72 eligible out-patients/subjects was conducted between July 1998 and November 2004. The participants were classified in three advanced heart failure groups (New York Heart Association Functional Classes II-III): Chagas' disease (n=15), ischemic (n=15) and idiopathic cardiomyopathy (n=15). Twelve Chagas' disease patients without heart failure and normal ejection fraction, and 15 normal controls were also studied. MSNA was recorded directly from the peroneal nerve by microneurography technique. MSNA was greater in heart failure patients when compared with Chagas' disease patients without heart failure (51+/-3 vs. 20+/-2 bursts/min P=0.0001). MSNA in Chagas' patients with norm...Continue Reading

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Citations

Oct 24, 2012·Interdisciplinary Perspectives on Infectious Diseases·Diego F DávilaBarbara Das Neves
Apr 2, 2009·International Journal of Cardiology·Giuseppe DattiloScipione Carerj
Dec 14, 2016·European Journal of Preventive Cardiology·Ligia M Antunes-CorreaCarlos E Negrao
Jun 24, 2011·European Journal of Preventive Cardiology·Ligia M Antunes-CorreaCarlos E Negrao
Feb 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Carlos E NegraoLigia M Antunes-Correa
Aug 30, 2020·ESC Heart Failure·Guilherme Wesley Peixoto da FonsecaStephan von Haehling

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