PMID: 8941514Nov 1, 1996Paper

Muscle tissue adaptations of high-altitude natives to training in chronic hypoxia or acute normoxia

Journal of Applied Physiology
D DesplanchesR Favier

Abstract

Twenty healthy high-altitude natives, residents of La Paz, Bolivia (3,600 m), participated in 6 wk of endurance exercise training on bicycle ergometers, 5 times/wk, 30 min/session, as previously described in normoxia-trained sea-level natives (H. Hoppeler, H. Howald, K. E. Conley, S. L. Lindstedt, H. Claassen, P. Vock, and E. R. Weibel. J. Appl. Physiol. 59: 320-327, 1985). A first group of 10 subjects was trained in chronic hypoxia (HT; barometric pressure = 500 mmHg; inspired O2 fraction = 0.209); a second group of 10 subjects was trained in acute normoxia (NT; barometric pressure = 500 mmHg; inspired O2 fraction = 0.314). The workloads were adjusted to approximately 70% of peak O2 consumption (VO2peak) measured either in hypoxia for the HT group or in normoxia for the NT group. VO2peak determination and biopsies of the vastus lateralis muscle were taken before and after the training program. VO2peak in the HT group was increased (14%) in a way similar to that in NT sea-level natives with the same protocol. Moreover, VO2peak in the NT group was not further increased by additional O2 delivery during the training session. HT or NT induced similar increases in muscle capillary-to-fiber ratio (26%) and capillary density (19%) as ...Continue Reading

References

May 1, 1991·Journal of Applied Physiology·B KayserP Cerretelli
Jul 1, 1991·Acta Physiologica Scandinavica·J D MacDougallC S Houston
Feb 1, 1991·Journal of Applied Physiology·G A BrooksJ T Reeves
Aug 1, 1990·Journal of Applied Physiology·D DesplanchesH Hoppeler
Jun 1, 1990·Journal of Applied Physiology·N TerradosL Kaijser
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R E Wilson, R M Sutherland
May 1, 1989·Journal of Applied Physiology·H J GreenC S Houston
Apr 1, 1985·Pflügers Archiv : European journal of physiology·H HowaldR Straub
Aug 1, 1985·Journal of Applied Physiology·H HoppelerE R Weibel
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·K RöslerH Howald
Oct 1, 1970·Archives of Neurology·M H Brooke, K K Kaiser
Dec 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G C ElderR Roberts
Apr 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J O Holloszy, E F Coyle
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
May 1, 1995·Journal of Applied Physiology·R FavierH Hoppeler
Jun 1, 1995·Journal of Applied Physiology·R FavierH Hoppeler
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·B W Rosser, P W Hochachka
Nov 1, 1993·Pflügers Archiv : European journal of physiology·D DesplanchesA Geyssant
Jul 1, 1993·International Journal of Sports Medicine·B KayserP Cerretelli
Feb 1, 1993·The American Journal of Physiology·A M CogswellD A Hood
Jul 1, 1996·Journal of Applied Physiology·B KayserP Cerretelli
Mar 1, 1962·Journal of Applied Physiology·B REYNAFARJE

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Citations

Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·H R WidmerE R Weibel
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·P W HochachkaK Kirsch
Jun 13, 2009·High Altitude Medicine & Biology·Martin Flueck
Jun 2, 2009·High Altitude Medicine & Biology·Paolo CerretelliClaudio Marconi
Jul 6, 2010·European Journal of Applied Physiology·T van WesselR T Jaspers
Jun 3, 2015·The Journal of Physiology·Andrew J Murray, James A Horscroft
Dec 12, 2018·Frontiers in Physiology·Gareth DavisonConor McClean
Oct 2, 1998·The American Journal of Physiology·G A BrooksJ T Reeves
Feb 5, 2000·Journal of Applied Physiology·H GreenD McKenzie
Dec 10, 1999·The Anatomical Record·A M LewisR D Gilbert
Jul 10, 2001·High Altitude Medicine & Biology·L G Moore
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Carsten LundbyPaul Robach
Sep 23, 2010·American Journal of Physiology. Endocrinology and Metabolism·Joachim NielsenNiels Ortenblad
Jun 12, 2016·Sports Medicine·David Montero, Carsten Lundby
Apr 22, 2018·Biochemical Society Transactions·Andrew J MurrayDaniel S Martin
May 5, 2005·Medicine and Science in Sports and Exercise·Renaud LegrandPatrick Mucci
May 8, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tom D Brutsaert
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·E DoussetY Jammes
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·R C I WüstH Degens
Apr 5, 2005·Pflügers Archiv : European journal of physiology·Marion FaucherMonique Badier
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cecilia GelfiPaolo Cerretelli
Oct 12, 2004·Muscle & Nerve·Roberto CasaleAlberto Rainoldi
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M Beall
Nov 5, 2008·Scandinavian Journal of Medicine & Science in Sports·G EliasonK Piehl-Aulin
Jun 18, 2017·Frontiers in Physiology·Stefan De SmetPeter Hespel
Sep 3, 2016·Acta Physiologica·D R Slivka
Jul 25, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·James E FaberHua Zhang
Apr 8, 1999·Journal of Applied Physiology·S B KanatousR W Davis
Jun 13, 2006·High Altitude Medicine & Biology·Claudio MarconiPaolo Cerretelli
Aug 11, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Pradeep P A MammenDaniel J Garry
Jun 12, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Comasia A RagusoClaude Pichard
Jun 15, 2021·Frontiers in Sports and Active Living·Alexandra MalgoyreHervé Sanchez

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