Muscle ultrasonography in the diagnosis of amyotrophic lateral sclerosis.

Neurological Research
Wang JuanGuo Junhong

Abstract

Objectives: The aims of this study were to investigate the differences of fasciculations detected by muscle ultrasonography (MUS) among patients with amyotrophic lateral sclerosis (ALS), patients with ALS mimics and healthy controls, and to propose a simplified MUS fasciculation score for the diagnosis of ALS.Methods: We included 16 patients with ALS (ALS group), 10 patients with ALS mimics (disease-control group), and 10 healthy adults (healthy control group). Subjects underwent MUS in 11 muscles, including the tongue, and bilateral upper trapezius, biceps brachii, abductor pollicis brevis, rectus femoris, and tibialis anterior.Results: The number of muscles with fasciculations per person was more in the ALS group (6.44 ± 2.56) than in the disease-control group (1.20 ± 1.87, P = 0.001) and healthy control group (0.50 ± 1.08, P < 0.001). Fasciculations in 3 of 11 muscles could predict the ALS diagnosis with high sensitivity (88.2%) and specificity (94.7%).Conclusions: Fasciculations detected by MUS can be a simple and useful diagnostic tool for ALS.

References

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Citations

Mar 12, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jing MaWei Zhang
Aug 26, 2021·International Journal of General Medicine·Andrew HannafordNeil G Simon

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Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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