Muscle wasting in cancer: the role of mitochondria

Current Opinion in Clinical Nutrition and Metabolic Care
Josep M ArgilésSílvia Busquets

Abstract

The aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia. Oxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling. An alteration of energy balance is the immediate cause of cachexia. Both alterations in energy intake and expenditure are responsible for the wasting syndrome associated with different types of pathological conditions, such as cancer. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss, one of which is mitochondrial dysfunction.

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Citations

May 12, 2016·Cancer Chemotherapy and Pharmacology·James C SorensenEmma Rybalka
Sep 20, 2016·Oxidative Medicine and Cellular Longevity·Mohamad Assi, Amélie Rébillard
Oct 22, 2016·Frontiers in Physiology·Gilles Gouspillou, Russell T Hepple
Nov 4, 2016·Frontiers in Physiology·Rafael BarretoAndrea Bonetto
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Sep 16, 2017·European Journal of Preventive Cardiology·Louise G Shewan
Oct 21, 2016·Muscle & Nerve·Alan PestronkRati Choksi
Jan 31, 2019·Journal of Cachexia, Sarcopenia and Muscle·Julien AniortDaniel Taillandier
Feb 23, 2019·Journal of Cachexia, Sarcopenia and Muscle·Cecilia MinagliaFiammetta Monacelli
Apr 5, 2019·Journal of Muscle Research and Cell Motility·Daria NeyroudRussell T Hepple
Apr 25, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica L HalleAndy V Khamoui
Feb 16, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Harold W LeeMelissa Puppa
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May 11, 2018·Oxidative Medicine and Cellular Longevity·Stefania GoriniElisabetta Ferraro
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Sep 29, 2020·Frontiers in Physiology·Brandon N VanderVeenJames A Carson
Feb 9, 2021·Experimental Biology and Medicine·Chenyuan LiShengrong Sun
Nov 17, 2020·Frontiers in Oncology·Marco InvernizziNicola Fusco
Feb 20, 2021·Journal of Muscle Research and Cell Motility·Charlotte HirouxPeter Hespel
May 11, 2021·The Biochemical Journal·Yonghua LiZhengzhi Zou

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