Muscle wasting in chronic kidney disease

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Eduardo A OliveiraRobert H Mak

Abstract

Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death. Children with CKD have many risk factors for lean mass and muscle wasting, including poor appetite, inflammation, growth hormone resistance, and metabolic acidosis. Mortality risks in patients with CKD increases as body mass index (BMI) and weight decreases. However, data regarding cachexia/PEW and muscle wasting in children with CKD is scarce due to lack of consensus in diagnostic criteria and an appropriate investigative methodology. Further research is urgently needed to address this important complication in the pediatric CKD setting, which may have fundamental impact on clinical outcomes.

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Citations

Jun 23, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Ke WangYing Shen
Apr 10, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Catherine Larson-Nath, Praveen Goday
Dec 14, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees
Mar 4, 2020·International Journal of Molecular Sciences·Keisuke HitachiKunihiro Tsuchida
Dec 24, 2019·Nursing Standard·Claire CarswellClare McKeaveney
Jul 8, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nur CanpolatSalim Caliskan
Mar 31, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaStella Stabouli
Dec 1, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yoshihiro YoshimuraAi Shiraishi
Jun 19, 2021·Seminars in Nephrology·Eduardo A OliveiraRobert H Mak
Aug 17, 2021·American Journal of Physiology. Renal Physiology·Elinor C MannonPaul M O'Connor

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