Muscling in on PGC-1α for improved quality of life in ALS

Cell Metabolism
Ashu Johri, M Flint Beal

Abstract

Impaired activity of peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α has been implicated in the pathophysiology of several neurodegenerative disorders. In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis.

Citations

Oct 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rachel TeslaAndrew A Pieper
Jul 17, 2021·Neural Regeneration Research·Jessica D PanesJorge Fuentealba

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