Muscularizing tissues in the endocardial cushions of the avian heart are characterized by the expression of h1-calponin

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Iris MoralezAndy Wessels

Abstract

Muscularization of mesenchymal tissues in the developing heart is an important event in the morphogenesis of the valvuloseptal complex in four-chambered hearts. Perturbation of muscularization has been implicated in the pathogenesis of cardiac malformations in several animal models for congenital heart disease, including the Trisomy 16 mouse and the TGFbeta2 knockout mouse. Studies to unravel the mechanism of muscularization, as well as studies to determine the extent of the process in frequently used animal-model systems for cardiac development, have, thus far, been hampered by the lack of useful differentiation markers for muscularizing tissues, albeit that it had been demonstrated that, in the mouse, muscularizing cells are characterized by an elevated level of smooth muscle actin expression. In this study, we investigated whether muscularization of endocardial cushions in the avian heart is also accompanied by the expression of smooth muscle cell markers. The results presented in this study demonstrate that, in quail and chick, a specific population of muscularizing cells is recognized by the expression of smooth muscle h1-calponin. Interestingly, other genes typically found in smooth muscle cells (e.g., smooth muscle actin...Continue Reading

References

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Citations

Mar 14, 2009·Differentiation; Research in Biological Diversity·Augusto OrlandiChristine Chaponnier
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brian S SnarrAndy Wessels
Nov 8, 2020·Journal of Cardiovascular Development and Disease·Maurice J B van den Hoff, Andy Wessels

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