Mushroom body glycolysis is required for olfactory memory in Drosophila

Neurobiology of Learning and Memory
Chia-Lin WuHsueh-Cheng Chiang

Abstract

Glucose catabolism, also known as glycolysis, is important for energy generation and involves a sequence of enzymatic reactions that convert a glucose molecule into two pyruvate molecules. The glycolysis process generates adenosine triphosphate as a byproduct. In this study, we investigated whether glycolysis plays a role in maintaining neuronal functions in the Drosophila mushroom bodies (MBs), which are generally accepted to be an olfactory learning and memory center. Our data showed that individual knockdown of glycolytic enzymes in the MBs, including hexokinase (HexA), phosphofructokinase (Pfk), or pyruvate kinase (PyK), disrupts olfactory memory. Whole-mount brain immunostaining indicated that pyruvate kinase is strongly expressed in the MB αβ, α'β', and γ neuron subsets. We conclude that HexA, Pfk, and PyK are required in each MB neuron subset for olfactory memory formation. Our data therefore indicates that glucose catabolism in the MBs is important for olfactory memory formation in Drosophila.

Citations

Oct 26, 2018·Molecular Neurobiology·Kuan-Cheng ChiDueng-Yuan Hueng
Nov 22, 2018·Frontiers in Cellular Neuroscience·Jenny B Koenig, Chris G Dulla
Apr 13, 2021·Frontiers in Behavioral Neuroscience·Deepthi MahishiWolf Huetteroth
Dec 4, 2021·Frontiers in Cell and Developmental Biology·Wang-Pao LeeChia-Lin Wu

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