Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila

The European Journal of Neuroscience
Christelle Redt-ClouetJean-Maurice Dura

Abstract

The remodelling of neurons during their development is considered necessary for their normal function. One fundamental mechanism involved in this remodelling process in both vertebrates and invertebrates is axon pruning. A well-documented case of such neuronal remodelling is the developmental axon pruning of mushroom body γ neurons that occurs during metamorphosis in Drosophila. The γ neurons undergo pruning of larval-specific dendrites and axons at metamorphosis, followed by their regrowth as adult-specific dendrites and axons. We recently revealed a molecular cascade required for this pruning. The nuclear receptor ftz-f1 activates the expression of the steroid hormone receptor EcR-B1, a key component for γ remodelling, and represses expression of Hr39, an ftz-f1 homologous gene. If ectopically expressed in the γ neurons, HR39 inhibits normal pruning, probably by competing with endogenous FTZ-F1, which results in decreased EcR-B1 expression. The mushroom bodies are a bilaterally symmetric structure in the larval and adult brain and are involved in the processing of different types of olfactory memory. How memory is affected in pruning-deficient adult flies that possess larval-stage neuronal circuitry will help to explain the f...Continue Reading

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Citations

Mar 13, 2014·Development, Growth & Differentiation·Abdel-Rahman S SultanHitoshi Ueda
Jun 3, 2014·Biochimica Et Biophysica Acta·Ana Boulanger, Jean-Maurice Dura
Dec 3, 2014·Insect Biochemistry and Molecular Biology·Xin-Ping LiuGuo-Qing Li
Sep 21, 2013·Developmental Biology·Jonathan ZirinNorbert Perrimon
Jul 4, 2015·Genetika·E V Savvateeva-PopovaA V Medvedeva
Jul 26, 2017·Frontiers in Psychiatry·Kristina CorthalsBart R H Geurten

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