Apr 10, 2015

Mushroom lectins: specificity, structure and bioactivity relevant to human disease

International Journal of Molecular Sciences
Mohamed Ali Abol HassanJ Tiralongo

Abstract

Lectins are non-immunoglobulin proteins that bind diverse sugar structures with a high degree of selectivity. Lectins play crucial role in various biological processes such as cellular signaling, scavenging of glycoproteins from the circulatory system, cell-cell interactions in the immune system, differentiation and protein targeting to cellular compartments, as well as in host defence mechanisms, inflammation, and cancer. Among all the sources of lectins, plants have been most extensively studied. However, more recently fungal lectins have attracted considerable attention due to their antitumor, antiproliferative and immunomodulatory activities. Given that only 10% of mushroom species are known and have been taxonomically classified, mushrooms represent an enormous unexplored source of potentially useful and novel lectins. In this review we provide an up-to-date summary on the biochemical, molecular and structural properties of mushroom lectins, as well as their versatile applications specifically focusing on mushroom lectin bioactivity.

Mentioned in this Paper

Immune System
Circulatory System
Immunoglobulin Activity
Agaricaceae
Glycoproteins
Cardiovascular System
Compartment Syndromes
Antineoplastic Agents, Phytogenic
Cell Communication
Immunoglobulins

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