Music exposure improves spatial cognition by enhancing the BDNF level of dorsal hippocampal subregions in the developing rats

Brain Research Bulletin
Yingshou XingDezhong Yao

Abstract

Previous research has shown that dorsal hippocampus plays an important role in spatial memory process. Music exposure can enhance brain-derived neurotrophic factor (BDNF) expression level in dorsal hippocampus (DH) and thus enhance spatial cognition ability. But whether music experience may affect different subregions of DH in the same degree remains unclear. Here, we studied the effects of exposure to Mozart K.448 on learning behavior in developing rats using the classical Morris water maze task. The results showed that early music exposure could enhance significantly learning performance of the rats in the water maze test. Meanwhile, the BDNF/TrkB level of dorsal hippocampus CA3 (dCA3) and dentate gyrus (dDG) was significantly enhanced in rats exposed to Mozart music as compared to those without music exposure. In contrast, the BDNF/TrkB level of dorsal hippocampus CA1 (dCA1) was not affected. The results suggest that the spatial memory improvement by music exposure in rats may be associated with the enhanced BDNF/TrkB level of dCA3 and dDG.

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Citations

Aug 1, 2018·Journal of Neuroscience Research·Xiaofan XiongChen Huang
Sep 2, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Preethy Sasidharan NairIrma Järvelä
Jan 9, 2019·Frontiers in Behavioral Neuroscience·A Y Rosalie KühlmannJohannes Jeekel
Jul 31, 2018·PeerJ·Heloísa H A BarcellosLeonardo J G Barcellos
Dec 29, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cristina RussoAntonella Russo

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