Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice

Transplantation Proceedings
M UchiyamaMasanori Niimi

Abstract

In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonge...Continue Reading

References

Dec 9, 1993·Nature·J C McLachlan
Apr 9, 2005·Southern Medical Journal·Kathi J Kemper, Suzanne C Danhauer
Oct 11, 2005·The Journal of Thoracic and Cardiovascular Surgery·Takeshi YokoyamaMasanori Niimi
Dec 16, 2005·Neurological Research·Peter AounMark Bodner
Feb 7, 2007·Behavioural Brain Research·Sachiko ChikahisaHiroyoshi Sei
May 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D IwamiM Niimi
Sep 10, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Anca AmagdeiAndrei C Miu
Jun 3, 2010·Brain Research·Wen-Jing LiZhe-Yu Chen

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Citations

Aug 12, 2014·Biochemical Pharmacology·Fulvio D'AcquistoGiuseppa Piras
Mar 6, 2015·Frontiers in Neuroscience·Tianyan Wang
Nov 1, 2015·Transplantation Proceedings·M UchiyamaM Niimi
Feb 26, 2014·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Elinor Gunning
Sep 30, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·Hans-Joachim Trappe
Nov 25, 2020·Journal of Cellular and Molecular Medicine·Meng-Xi XiuWen-Jun Wang
Mar 9, 2021·Frontiers in Immunology·Andi ZhangMingliang Xiang

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