Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation

Brain Research
Den'etsu Sutoo, Kayo Akiyama

Abstract

The mechanism by which music modifies brain function is not clear. Clinical findings indicate that music reduces blood pressure in various patients. We investigated the effect of music on blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that calcium increases brain dopamine (DA) synthesis through a calmodulin (CaM)-dependent system. Increased DA levels reduce blood pressure in SHR. In this study, we examined the effects of music on this pathway. Systolic blood pressure in SHR was reduced by exposure to Mozart's music (K.205), and the effect vanished when this pathway was inhibited. Exposure to music also significantly increased serum calcium levels and neostriatal DA levels. These results suggest that music leads to increased calcium/CaM-dependent DA synthesis in the brain, thus causing a reduction in blood pressure. Music might regulate and/or affect various brain functions through dopaminergic neurotransmission, and might therefore be effective for rectification of symptoms in various diseases that involve DA dysfunction.

References

Jan 1, 1990·Alzheimer Disease and Associated Disorders·E K PerryA F Fairbairn
Jun 1, 1989·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·A Hurwitz
Mar 1, 1989·Brain Research Bulletin·D SutooM Geffard
Oct 11, 1988·European Journal of Pharmacology·D SutooK Akiyama
Nov 1, 1986·Clinical Endocrinology·S LjunghallG Akerström
Oct 1, 1986·Archives of Physical Medicine and Rehabilitation·S S PalmerG L Dickinson
Oct 1, 1985·Pharmacology, Biochemistry, and Behavior·D SutooK Iimura
Jul 1, 1967·Analytical Biochemistry·B C Sarkar, U P Chauhan
Apr 1, 1994·Calcified Tissue International·H SalvesenS Ljunghall
Jul 1, 1996·Physiology & Behavior·D E Sutoo, K Akiyama
Mar 1, 1997·Clinical Nurse Specialist CNS·G R Watkins
Dec 10, 1999·Medicine and Science in Sports and Exercise·I ReuterH Baas
Jul 15, 2000·Archives of Physical Medicine and Rehabilitation·I MiyaiJ Kang
Sep 16, 2000·Archives of Gerontology and Geriatrics·J Lökk
Apr 5, 2001·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·V N Sidorenko
Jul 10, 2001·Experimental Aging Research·N A Foster, E R Valentine
Feb 28, 2002·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·W J Hamel
Jul 20, 2002·Progress in Neurobiology·André Nieoullon
Nov 12, 2002·Behavioural Processes·Jaak Panksepp, Günther Bernatzky
Mar 1, 2003·Epilepsy & Behavior : E&B·John R. Hughes
May 22, 2003·Neurobiology of Disease·Den'etsu Sutoo, Kayo Akiyama

❮ Previous
Next ❯

Citations

Jun 22, 2011·Behavioral Neuroscience·J E Polston, S D Glick
Jan 24, 2013·Lab Animal·Leanne C Alworth, Shawna C Buerkle
May 23, 2012·Epilepsia·Melissa Jane Maguire
May 17, 2014·International Archives of Medicine·Simone F RegaçoneAna Cf Frizzo
Apr 29, 2014·Complementary Therapies in Clinical Practice·Ariany G da SilvaVitor E Valenti
Mar 1, 2012·Journal of Physiology and Biochemistry·Inmaculada TassetPedro Montilla
Mar 20, 2013·Journal of Psychiatric Practice·Rosa Quelhas
Oct 2, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Aaron NelsonClaudius Conrad
Apr 17, 2014·The Gerontologist·Matt BradshawCollin Mueller
Jul 22, 2015·Expert Review of Neurotherapeutics·Huan LiaoXuefeng Wang
Aug 14, 2012·Pharmacology, Biochemistry, and Behavior·J E PolstonS D Glick
Jun 14, 2016·Journal of Racial and Ethnic Health Disparities·Joseph Keawe'aimoku KaholokulaKa'imi A Sinclair
Sep 10, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Anca AmagdeiAndrei C Miu
Mar 17, 2007·Neuroscience Letters·Takuo NakamuraKatsuya Nagai
Mar 26, 2015·Scientific Reports·Chakravarthi KanduriIrma Järvelä
Apr 25, 2012·Annals of the New York Academy of Sciences·Teppo Särkämö, David Soto
Jul 15, 2015·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Lolita MercadíeEmmanuel Bigand
Jan 1, 2008·IEEE Reviews in Biomedical Engineering·Xiao-Fei TengPaolo Bonato
Jul 11, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Urs M NaterUlrike Ehlert
Mar 12, 2016·Journal of Alzheimer's Disease : JAD·Katlyn J PeckAlexandra J Fiocco
Dec 15, 2010·Pharmacology, Biochemistry, and Behavior·J E PolstonS D Glick
Apr 2, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lung-Chang LinRei-Cheng Yang
Apr 21, 2016·BMC Cardiovascular Disorders·Anne Y R KühlmannJohanna J M Takkenberg
Feb 5, 2011·Epilepsy & Behavior : E&B·Lung-Chang LinRei-Cheng Yang
Aug 19, 2014·Complementary Therapies in Clinical Practice·Juliana Cristina BarbosaVitor E Valenti
Mar 20, 2015·PeerJ·Chakravarthi KanduriIrma Järvelä
Jul 30, 2014·Frontiers in Human Neuroscience·Françoise RochetteEmmanuel Bigand
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lung-Chang LinRei-Cheng Yang
Dec 22, 2016·Journal of Psychosocial Nursing and Mental Health Services·Robert H Howland
Jun 11, 2017·Brain Research Bulletin·Cristina RussoStefania Stanzani
Apr 6, 2006·Behavioral and Cognitive Neuroscience Reviews·Nikki S RickardSimone E Field
Dec 15, 2017·The Open Dentistry Journal·Tantry MaulinaM Nurhalim Shahib

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.