Musical chairs during mitophagy

Autophagy
Joern Dengjel, Hagai Abeliovich

Abstract

Mitophagy, or the autophagic degradation of mitochondria, is thought to be important in mitochondrial quality control, and hence in cellular physiology. Defects in mitophagy correlate with late onset pathologies and aging. Here, we discuss recent results that shed light on the interrelationship between mitophagy and mitochondrial dynamics, based on proteomic analyses of protein dynamics in wild-type and mutant cells. These studies show that different mitochondrial matrix proteins undergo mitophagy at different rates, and that the rate differences are affected by mitochondrial dynamics. These results are consistent with models in which phase separation within the mitochondrial matrix leads to unequal segregation of proteins during mitochondrial fission. Repeated fusion and fission cycles may thus lead to "distillation" of components that are destined for degradation.

Citations

Jul 12, 2014·BioMed Research International·Mónika Lippai, Péter Lőw
Jul 22, 2015·Mitochondrion·Davide Alessandro Basello, Anna Ivana Scovassi
Aug 5, 2016·Cell and Tissue Research·Jörn Dengjel, Hagai Abeliovich
Nov 19, 2014·Hypertension·Alfonso EirinLilach O Lerman
Nov 12, 2014·European Heart Journal·Alfonso EirinLilach O Lerman
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Panagiota KolitsidaHagai Abeliovich
Apr 14, 2016·Biochemical Society Transactions·Hagai Abeliovich, Jörn Dengjel

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