Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Biomaterials
Hyo Jeong KimHyung Joon Cha

Abstract

Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy-l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.

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Citations

Sep 21, 2016·Journal of Biomedical Materials Research. Part a·Bum Jin KimHyung Joon Cha
Dec 6, 2017·Advanced Healthcare Materials·Nikhil PandeyYi Hong
Jan 23, 2018·Advanced Materials·Anton H HofmanMarleen Kamperman
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Nov 15, 2016·Advanced Functional Materials·Wei WeiJ Herbert Waite
Feb 4, 2021·ACS Applied Materials & Interfaces·Jaemin HwangJin Woong Kim
Mar 3, 2021·Acta Biomaterialia·Hyo Jeong KimHyung Joon Cha
Jul 30, 2020·International Journal of Biological Macromolecules·Adarsha H J GowdaAbhay Pandit
Aug 5, 2021·ACS Applied Materials & Interfaces·Jun-Sung KimHaeshin Lee
Aug 30, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Pierluigi BilottoBruno Zappone
Nov 28, 2018·ACS Applied Materials & Interfaces·Eugene KimFuzhong Zhang
Apr 3, 2020·ACS Applied Materials & Interfaces·Daiheon LeeHaeshin Lee
Nov 21, 2020·Biomacromolecules·Yifan ZhangXiaoya Liu
Sep 18, 2021·Advanced Materials·Hailong Fan, Jian Ping Gong
Oct 9, 2021·Chemistry : a European Journal·Jing SunHongjie Zhang

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