Mussel-inspired dual-functional PEG hydrogel inducing mineralization and inhibiting infection in maxillary bone reconstruction

Materials Science & Engineering. C, Materials for Biological Applications
Huiyong XuXiaozhong Qiu

Abstract

Infection compromises healing process after bone fracture. An anti-bacterial bone graft synthesized from polymer and mineralization components is becoming preferable for its accessibility and low cost and tunable chem-physic properties. In this study, mussel-inspired polydopamine (PDA) was used to synthesize in-situ silver nanoparticles (AgNPs) and mineralization on polyethylene hydrogel (PEG). With dual functions of anti-bacteria and graft mineralization, we found the hydrogel (AgNPs/PDA) promoted bone generation and show significant antibacterial activity. Specifically, the gel upregulated the expression of osteogenic genes of bone sialoprotein gene, alkaline phosphatase, osteocalcin and runt-related transcription factor 2. It also significantly inhibited the growth of Staphylococcus aureus and Escherichia coli. In vivo the AgNPs/PDA gel could repair maxillary bone defect efficiently.

Citations

Feb 14, 2019·Bioengineering·Hui-Li TanJanarthanan Pushpamalar
Sep 27, 2019·Journal of Oral Rehabilitation·Hong WangFulan Wei
Sep 27, 2018·International Journal of Molecular Sciences·Liying LiuHuawei He
Oct 22, 2020·International Journal of Biological Macromolecules·Laijun XuJiyao Li

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