Mussel-Inspired, Surface-Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Macromolecular Rapid Communications
Yajuan SuWei Huang

Abstract

In this work, a novel biomimetic surface-attachable initiator is successfully synthesized by the conjugation of 3,4-dihydroxyphenylacetic acid and thermal 2,2'-azobis(2-methylpropionamide) dihydrochloride (V-50). The synthesized initiator (DOPV) can adhere to various material surfaces in a mussel-inspired way and initiate the surface grafting polymerization. Hydrogel coatings are facilely prepared by the thermal-initiated radical copolymerization of antimicrobial polyhexamethylene guanidine and antifouling polyethylene glycol oligomers. The developed hydrogel coatings not only show antimicrobial activity toward gram-negative and gram-positive bacteria but also demonstrate protein resistance, antibiofilm efficacy, hemocompatibility, and low cytotoxicity in vitro. Most importantly, the hydrogel coatings reveal excellent antimicrobial efficacy with a log reduction above 5 in a rodent subcutaneous infection model. These results demonstrate the potential fabrication of bio-functional coatings for biomedical devices or implants through an inexpensive, facile, and environmentally friendly mussel-inspired technique.

References

Mar 22, 2001·Biochemistry·J H Waite, X Qin
Nov 10, 2005·Journal of the American Chemical Society·Xiaowu FanPhillip B Messersmith
Oct 20, 2007·Science·Haeshin LeePhillip B Messersmith
Dec 28, 2007·Materials Science & Engineering. R, Reports : a Review Journal·Gregory J GabrielGregory N Tew
Sep 1, 2009·Journal of the American Chemical Society·Sung Min KangHaeshin Lee
May 14, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Wen Jing YangDaniel Rittschof
May 24, 2011·Chemical Society Reviews·Qian YeWeimin Liu
Sep 20, 2012·The Journal of Physical Chemistry. B·Jessie PeyreClaire-Marie Pradier
Nov 20, 2014·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Suganthan VeerachamyPrasad Kdv Yarlagadda
Jan 30, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I Olsen
Feb 12, 2015·Journal of Medical Microbiology·Steven L PercivalGianfranco Donelli
Jul 30, 2015·Biomaterials Science·G T QinC Z Cai
Dec 17, 2016·ACS Applied Materials & Interfaces·Jin GuPeng Yang
Nov 7, 2017·Polymer Chemistry·Melissa L HawkinsMelissa A Grunlan
Feb 22, 2018·ACS Applied Materials & Interfaces·Ji Hyun RyuHaeshin Lee
Jan 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingcai HeLi Ren
Apr 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Junjian ChenYingjun Wang

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Citations

Sep 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xianghong WangShifang Luan
Mar 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhuangzhuang QiaoJianbin Luo
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Chao ZhouVinh X Truong
Oct 4, 2020·Advances in Colloid and Interface Science·Changwen ZhaoWantai Yang
Apr 17, 2021·Journal of Hazardous Materials·Jiangmei PengJian Shen

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