Mutacin II, a bactericidal antibiotic from Streptococcus mutans.

Antimicrobial Agents and Chemotherapy
M L ChikindasP W Caufield

Abstract

Mutacin II is an antibiotic that is produced by group II Streptococcus mutans. It inhibits the growth of other streptococci as well as many other gram-positive microorganisms by a hitherto unknown mechanism. Mutacin II possess bactericidal activity against susceptible cells. It transiently depolarizes the transmembrane electrical potential (delta psi) and the transmembrane pH gradient (delta pH) and partially inhibits amino acid transport. However, it rapidly depletes the intracellular ATP pool in glucose-energized cells and prevents the generation of ATP. It is concluded that mutacin II does not belong to the group of pore-forming antibiotics (type A) or to the type B antibiotics, which inhibit phospholipases or interfere with peptidoglycan biosynthesis. Mutacin II acts by inhibiting essential enzyme functions at the level of metabolic energy generation, an activity that has not yet been classified for antibiotics.

References

Oct 1, 1975·Archives of Oral Biology·S Hamada, T Ooshima
May 15, 1992·Archives of Biochemistry and Biophysics·J T HendersonP D van Wassenaar
Nov 14, 1991·Biochimica Et Biophysica Acta·D MolenaarW N Konings
Jan 1, 1989·Critical Reviews in Microbiology·W N KoningsA J Driessen
Mar 1, 1969·Archives of Oral Biology·J Kelstrup, R J Gibbons
Jun 15, 1995·European Journal of Biochemistry·H G SahlG Bierbaum

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Citations

Jul 10, 2008·International Journal of Antimicrobial Agents·M L ChikindasJ R Tagg
May 21, 2008·Antimicrobial Agents and Chemotherapy·Hideo YonezawaHidenobu Senpuku
Nov 14, 2006·Journal of Bacteriology·Ingolf F NesHelge Holo
Dec 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Howard K KuramitsuWenyuan Shi
Sep 3, 2009·Future Microbiology·Philip A WescombeJohn R Tagg
Apr 28, 2009·Journal of Bioscience and Bioengineering·Sikder M Asaduzzaman, Kenji Sonomoto
Jul 30, 2009·Journal of Separation Science·Bob StanleyKingsley K Donkor
Nov 14, 2006·FEMS Microbiology Reviews·Alain DufourJean-Paul Le Pennec
Dec 22, 1999·The Journal of the American Dental Association·H C Slavkin
Jul 29, 2016·Nature·Kim Lewis, Philip Strandwitz
Oct 19, 2006·Journal of Bioscience and Bioengineering·Jun-ichi NagaoKenji Sonomoto
Aug 17, 2016·Scientific Reports·Abdelahhad BarbourKoshy Philip
Mar 20, 2015·Microbiology and Molecular Biology Reviews : MMBR·Lorraine A DraperR Paul Ross
Jun 1, 2011·Probiotics and Antimicrobial Proteins·Adam Pepperney, Michael L Chikindas
May 24, 2000·The Journal of Biological Chemistry·R E KrullP W Caufield
Apr 4, 2021·International Journal of Molecular Sciences·Hideo YonezawaShigeru Kamiya
Feb 11, 2005·Chemical Reviews·Champak ChatterjeeWilfred A van der Donk
Aug 26, 2017·Microbiology Spectrum·Anilei HoarePatricia I Diaz

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