PMID: 8986771Dec 24, 1996Paper

Mutagenesis associated with nitric oxide production in transgenic SJL mice

Proceedings of the National Academy of Sciences of the United States of America
A Gal, Gerald N Wogan

Abstract

We recently reported development of an experimental model for the study of nitric oxide (NO.) toxicology in vivo. SJL mice were injected with superantigen-bearing RcsX (pre-B-cell lymphoma) cells, which migrated to the spleen and lymph nodes, where their rapid growth induced activation of macrophages to produce large amounts of NO. over a period of several weeks. In the experiments described here, we used this model to investigate mutagenesis in splenocytes exposed to NO. during RcsX cell growth. Transgenic mice were produced by crossbreeding animals of the pUR288 transgenic C57BL/6 and SJL strains. RcsX cells were injected into F1 mice and NO. production was confirmed by quantification of urinary nitrate, the ultimate metabolite of NO. Mutant frequency in the lacZ gene of the pUR288 plasmid was determined in DNA isolated from spleen (target) and kidney (nontarget) tissues. A significant elevation in mutant frequency was found in the spleen, but not in the kidney, of tumor-bearing mice. Furthermore, increases in mutant frequency in the spleen as well as NO. production were abrogated by administration of N-methylarginine, a NO. inhibitor, to mice following injection of RcsX cells. These results indicate that NO. had mutagenic ac...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T NguyenS R Tannenbaum
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S W KohlerJ M Short
Jan 1, 1991·Free Radical Biology & Medicine·M A Trush, T W Kensler
Jun 1, 1989·European Journal of Immunology·J StavnezerG J Thorbecke
Jul 1, 1986·International Reviews of Immunology·N M PonzioG J Thorbecke
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jun 1, 1994·Mutation Research·D M ParisisW G Henderson
Oct 1, 1995·Mutation Research·X B ZhangJ A Heddle
Oct 1, 1995·Mutation Research·H J MartusJ Vijg
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P BaronM A Cassatella
Jan 1, 1995·Environmental and Molecular Mutagenesis·W W PiegorschK R Tindall
Sep 1, 1994·Chemical Research in Toxicology·M N RoutledgeA Dipple
Jan 1, 1994·Environmental and Molecular Mutagenesis·W W PiegorschM D Shelby
May 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A T LeeR Bucala
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Dec 1, 1995·Toxicology Letters·B BrüneK Sandau
Jul 1, 1996·Chemical Research in Toxicology·S TamirS R Tannenbaum
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A GalG N Wogan

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Citations

Feb 26, 2000·Environmental and Molecular Mutagenesis·J C ZhuangG N Wogan
Jan 11, 2001·Environmental and Molecular Mutagenesis·J C ZhuangG N Wogan
Sep 22, 2001·Electrophoresis·J StulíkP R Jungblut
Mar 23, 2001·Reviews in Medical Virology·T Akaike
Jul 20, 2007·Molecular and Cellular Biochemistry·Abhijit G BanerjeeJamboor K Vishwanatha
Mar 3, 2004·Archives of Biochemistry and Biophysics·Peter C Dedon, Steven R Tannenbaum
Feb 10, 2000·The American Journal of Pathology·J K SandhuH C Birnboim
Aug 19, 2003·Archives of Biochemistry and Biophysics·Hiroshi OhshimaTomohiro Sawa
May 6, 2003·Gastroenterology·Eliette TouatiAgnès Labigne
Mar 5, 1999·Mutation Research·S BurneyS R Tannenbaum
Apr 10, 2003·Free Radical Biology & Medicine·Lorne J HofsethCurtis C Harris
Mar 21, 2002·The Lancet Oncology·P K Lala, C Chakraborty
Mar 20, 2013·Chemical Research in Toxicology·Erin G PrestwichPeter C Dedon
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·S E ErdmanJ G Fox
Dec 17, 2008·The Journal of Biological Chemistry·Binbin RenHuangen Ding
Jun 30, 2010·Carcinogenesis·Nicholas J ClemonsRebecca C Fitzgerald
Jan 16, 1999·Journal of the National Cancer Institute·S AmbsC C Harris
Nov 8, 2001·Journal of the National Cancer Institute·A J MarrogiC C Harris
Jun 12, 2002·Journal of Bacteriology·Erik J SpekBevin P Engelward
Jul 29, 2004·Journal of Virology·Jun YoshitakeHiroshi Maeda
Oct 28, 2010·The Journal of Clinical Investigation·Sharon A GlynnStefan Ambs
May 31, 2013·World Journal of Surgical Oncology·Sheetal Korde ChoudhariVaishali Joshi
Feb 8, 2011·Journal of Clinical Biochemistry and Nutrition·Hideshi IharaTakaaki Akaike
Aug 1, 2007·Biomarkers in Medicine·Peter C DedonBo Pang
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J C Zhuang, G N Wogan
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·S AmbsC C Harris
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·J C ZhuangG N Wogan
Mar 23, 2011·FEBS Letters·Denise E de AlmeidaJoseph Holoshitz
Apr 24, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sung Wook HwangIn Sung Song
Feb 24, 2012·Oral Oncology·Sheetal Korde ChoudhariV Poornima
Nov 2, 2011·DNA Repair·James T MutambaBevin P Engelward
Oct 30, 2007·Mutation Research·Zhanna SobolRobert H Schiestl
Oct 21, 2010·Annals of the New York Academy of Sciences·Joseph HoloshitzSong Ling
Nov 29, 2005·Nitric Oxide : Biology and Chemistry·Teruo AkutaTakaaki Akaike
Aug 9, 2005·Mutation Research·Hiroshi OhshimaTomohiro Sawa
Dec 4, 2001·Nitric Oxide : Biology and Chemistry·I ShokolenkoF M Robertson

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