PMID: 6163076Jan 1, 1981Paper

Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. IV. Comparison of dose-response curves for MNNG, 4NQO and ICR-170 induced inactivation and mutation-induction

Mutation Research
Hirokazu InoueF J de Serres

Abstract

The genetic effects of MNNG, 4NQO and ICR-170 have been compared on 5 different UV-sensitive strains and a standard wild-type strain of Neurospora crassa with regard to inactivation and the induction of forward-mutations at the ad-3A and ad-3B loci. Whereas all UV-sensitive strains (upr-1, uvs-2, uvs-3, uvs-5 and uvs-6) are more sensitive to inactivation by MNNG and ICR-170 than wild-type, only uvs-5 shows survival comparable to wild-type after 4NQO treatment, all other strains are more sensitive to 4NQO. In contrast to the effects on inactivation, a wide variety of effects were found for the induction of ad-3A and ad-3B mutations: higher forward-mutation frequencies than were found in wild-type were obtained after treatment with MNNG or 4NQO for upr-1 and uvs-2, no significant increase over the spontaneous mutation frequency was found with uvs-3 after MNNG, 4NQO or ICR-170 treatment; mutation frequencies comparable to that found in wild-type were obtained with uvs-6 after MNNG, 4NQO or ICR-170 treatment and with upr-1 after ICR-170 treatment. Lower forward-mutation frequencies than were found in wild-type were obtained with uvs-2 after ICR-170 treatment and with uvs-5 after MNNG, 4NQO or ICR-170 treatment. These data clearly s...Continue Reading

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Citations

Sep 1, 1984·Mutation Research·W G DeGraff
Jan 1, 1987·Free Radical Biology & Medicine·I H Goldberg
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·S TateishiM Yamaizumi
Jul 27, 2005·Ecotoxicology and Environmental Safety·Giovanni Pontecorvo, Stefania Fantaccione
Aug 28, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephen D DertingerJames T Macgregor
Dec 1, 1982·Microbiological Reviews·D D PerkinsM Björkman

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