Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species.

Molecular Biology and Evolution
Mohamed A F Noor

Abstract

Local rates of recombination positively correlate with DNA sequence diversity in many species. To test whether this relationship stems from mutagenicity of meiotic recombination, studies often look for a similar association between local rates of recombination and sequence "divergence" between species. Because recombination is mutagenic in yeast, I evaluate this assay by testing whether noncoding DNA sequence divergence between Saccharomyces species is related to measures of meiotic double-strand DNA breaks or crossover rates derived from Saccharomyces cerevisiae. Contrary to expectation, I find that sequence divergence is either uncorrelated or negatively correlated with rates of both double-strand break and crossover. Several caveats are mentioned, but these results suggest that mutagenesis from meiotic recombination is not the primary driver of sequence divergence between Saccharomyces species. This study demonstrates that the association between interspecies nucleotide divergence and local recombination rates is not always a reliable indicator of recombination's mutagenicity.

References

Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Jul 1, 1995·Genetics·J N StrathernC B McGill
May 1, 1993·Current Genetics·M S Esposito, C V Bruschi
Aug 1, 1993·Genetics·B CharlesworthD Charlesworth
Apr 1, 1996·Genetical Research·M NordborgD Charlesworth
Oct 25, 1996·Science·A GoffeauS G Oliver
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·F Baudat, A Nicolas
Feb 20, 1998·Current Opinion in Genetics & Development·C F Aquadro
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·J L GertonT D Petes
May 22, 2002·International Journal of Occupational and Environmental Health·Nicholas A AshfordAndrew Watterson
Jul 20, 2002·Trends in Genetics : TIG·Martin J Lercher, Laurence D Hurst
Nov 16, 2002·Current Opinion in Genetics & Development·Michael W Nachman
May 13, 2003·American Journal of Human Genetics·Ines HellmannMolly Przeworski
Sep 10, 2003·Journal of Molecular Evolution·Richard M KlimanMaria Santiago
May 1, 1962·The Anatomical Record·H G MOSER, K BENIRSCHKE
Nov 8, 2003·Gene·Dmitry A Filatov, Dave T Gerrard
Mar 12, 2004·Molecular Biology and Evolution·Maud I TenaillonBrandon S Gaut
Apr 3, 2004·Genome Research·Mathieu BlanchetteWebb Miller
Jun 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Joshua D HawkRosann A Farber
Jun 16, 2005·Genetics·Justin C Fay, Joseph A Benavides
Aug 10, 2005·Genome Biology·Penelope R HaddrillPeter Andolfatto
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Julie Akiko HeckEric Alani
Mar 18, 2006·Human Molecular Genetics·Rita Neumann, Alec J Jeffreys
Sep 27, 2006·Yeast·Dianna G FiskUNKNOWN Saccharomyces Genome Database Project
Mar 14, 2007·PLoS Genetics·Graham Coop, Simon R Myers
Apr 10, 2007·Trends in Genetics : TIG·Nicolas Galtier, Laurent Duret
May 29, 2007·PLoS Computational Biology·Scott W Doniger, Justin C Fay
Jun 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael LynchW Kelley Thomas
Jul 11, 2008·Nature·Eugenio ManceraLars M Steinmetz
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rob J KulathinalMohamed A F Noor

❮ Previous
Next ❯

Citations

Oct 5, 2010·Journal of Molecular Evolution·Laurie S Stevison, Mohamed A F Noor
Jun 16, 2011·Heredity·C S Smukowski, M A F Noor
Mar 13, 2013·Nature Reviews. Genetics·Asher D Cutter, Bret A Payseur
Jan 1, 2009·Genome Biology and Evolution·Claudia C Weber, Laurence D Hurst
Jan 5, 2011·Molecular Biology and Evolution·Asher D Cutter, Alan M Moses
Apr 2, 2010·Genome Research·Niclas BackströmHans Ellegren
Nov 16, 2012·PLoS Biology·Suzanne E McGaughMohamed A F Noor
May 10, 2012·PLoS Genetics·Kiwoong Nam, Hans Ellegren
Jan 21, 2011·PloS One·Marie-Claude Marsolier-Kergoat
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Isheng J TsaiVassiliki Koufopanou
Dec 14, 2011·Trends in Genetics : TIG·Matthew T Webster, Laurence D Hurst
Jan 9, 2015·PLoS Genetics·Alison RattrayJeffrey N Strathern
Aug 11, 2016·PLoS Genetics·Tanya N PhungKirk E Lohmueller
Aug 9, 2017·Journal of Evolutionary Biology·M RavinetA M Westram
Mar 29, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ayelet Arbel-Eden, Giora Simchen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Rob J KulathinalMohamed A F Noor
Proceedings of the National Academy of Sciences of the United States of America
Isheng J TsaiVassiliki Koufopanou
© 2022 Meta ULC. All rights reserved