PMID: 7025199Aug 1, 1981Paper

Mutagenic activity in the River Meuse in Belgium

The Science of the Total Environment
F Van Hoof, J Verheyden

Abstract

Frameshift mutagens have been detected in the river Meuse downstream of Liège In most cases, mutagenic activity could only be demonstrated afte metabolic activation. The effect was inversely related to river flow. The most important sewage outfalls and industrial discharges in the area were controlled on mutagenic activity. Two effluents, both discharging cokes-oven effluents, were found to contain high quantities of frameshift mutagens. The effluents were split up in neutral, acidic and basic fractions. Only neutral and basic fractions showed mutagenic activity. They were further separated in subfractions by gel chromatography and adsorption chromatography. The mutagenic activity was shown to be present in subfractions containing polynuclear aromatic hydrocarbons and aza-arenes. Mutagenic activity in river water samples could only be located in the polynuclear aromatic hydrocarbon fractions.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
May 1, 1978·The Science of the Total Environment·A E PreinC L Poels
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Citations

Sep 1, 1987·Archives of Environmental Contamination and Toxicology·O C PancorboR D Blevins
Oct 1, 1987·Bulletin of Environmental Contamination and Toxicology·S Oishi, O Takahashi
Sep 21, 2007·Environmental Monitoring and Assessment·Jung-Hwan KwonYong-Hwa Kim
Nov 1, 1988·Mutation Research·J R Meier
Aug 1, 1992·Mutation Research·V S Houk
Sep 1, 1983·Mutation Research·T SatoK Kato
Dec 1, 1992·Mutation Research·M OmuraN Ishinishi
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D G WaltonH F Stich
Jan 1, 1993·Pharmacology & Toxicology·P A Nielsen
Aug 1, 1996·Drug and Chemical Toxicology·V S Houk, M D Waters

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