PMID: 7019691Apr 1, 1981Paper

Mutagenic activity of benzofurans and naphthofurans in the Salmonella/microsome assay: 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000), a new highly potent mutagenic agent

Mutation Research
N Weill-ThevenetM Hofnung

Abstract

A series of benzofurans and naphthofurans was examined through the Salmonella/microsome assay. (i) With one possible exception, only 2-nitro derivatives give a mutagenic response. However, it appears that the mutagenic potency depends notably on the nature and the position of the other substituents in the molecule. (ii) The mutagenic response occurs in strains TA1537, TA1538, TA98 and TA100 but not in strain TA1535. Reversion of the missense mutation of TA1535 is thus induced only in presence of the plasmid pKM101. (iii) This mutagenic response is at least partially dependent on the bacterial nitroreductase activities and is usually lower in presence of activating mixture from rat liver. (iv) One of the compounds tested, 2-nitro-7-methoxynaphtho[2,1-b]furan (R7000), may be the most potent mutagen examined so far in the Salmonella/microsome assay. It yields about 200 000 revertants/nanomole on strain TA100 in the standard plate test. The relation between structure, mutagenic potency and other biological activities of the compounds are briefly discussed.

References

Jul 1, 1976·Biochemical Pharmacology·H S Rosenkranz, W T Speck
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
May 1, 1980·Mutation Research·E Kalinowska, M Chorazy

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Citations

May 1, 1992·Chemico-biological Interactions·H StrapeliasM Duquesne
Feb 1, 1988·Mutation Research·P QuillardetM Hofnung
Apr 1, 1982·Mutation Research·N Weill-ThevenetM Hofnung
Jul 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T B AdamsR A Ford
Nov 1, 1991·Mutation Research·N Danford
Mar 1, 1997·Toxicology and Applied Pharmacology·S Cantoreggi, D A Keller
Feb 1, 1985·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J C MaurizisR Royer
Jul 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J C MaurizisJ L Chabard
Jan 1, 1995·Environmental and Molecular Mutagenesis·J F HatcherS Swaminathan
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi
Jan 1, 1993·Free Radical Research Communications·R ZalmaM Duquesne
Jan 27, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ashraf H F Abd El-WahabAhemed M El-Agrody
Nov 1, 1986·Digestive Diseases and Sciences·D A JohnsonA Dubois
May 1, 1987·Journal of Bacteriology·K GehringM Hofnung

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