PMID: 6402690Jan 1, 1983Paper

Mutagenic activity of selected aromatic amines and polycyclic hydrocarbons in Drosophila melanogaster

Mutation Research
E W VogelW G Blijleven

Abstract

With the use of a series of wild-type and repair-deficient strains and appropriate application procedures, it is possible to demonstrate that carcinogenic aromatic amines and polycyclic hydrocarbons are mutagens in Drosophila. We have shown evidence that AAF, N-OH-AAF, AcO-AAF, BP, DAS and DMBA produce recessive lethals when fed to or injected into adult males. Mutagenic activity was also observed when male larvae were exposed to AAF, BP, DMBA, 3-MC or NA. DA was not mutagenic in the recessive lethal assay under the conditions of the test. DMBA can now be considered as a potent mutagen for Drosophila, although demonstration of its activity depends upon the choice of the treatment procedure and the strain selected. One of the questions concerning the action of aromatic amines and polycyclic hydrocarbons is how their genetic effectiveness in Drosophila can be enhanced. The observation that none of several enzyme inducers (PB, BF, AC, 3-MC) increased their mutagenicity may be interpreted in terms of a more efficient metabolic activation or deactivation. This assumes that active metabolite(s) did not reach the testis in doses sufficient for mutation induction. It also appears that, since the problems pertaining to mutagenicity in D...Continue Reading

References

Nov 1, 1979·Mutation Research·T D NguyenM M Green
Mar 15, 1972·International Journal of Cancer. Journal International Du Cancer·O G Fahmy, M J Fahmy
Jan 1, 1966·Current Topics in Developmental Biology·H J Becker
Jan 1, 1980·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·A J BaarsD D Breimer

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Citations

Mar 1, 1984·Chemico-biological Interactions·J A ZijlstraD D Breimer
Nov 1, 1982·Mutation Research·V W Mayer
Sep 1, 1983·Mutation Research·P S ChauhanU H Ehling
Sep 9, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sukeo Onodera
Mar 1, 1992·Mutation Research·S ZimmeringJ Guzman
Sep 28, 1984·Biochemical and Biophysical Research Communications·L C WatersC E Nix
Jan 1, 1984·Environmental Mutagenesis·U GrafP G Kale

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