PMID: 6991931May 1, 1980Paper

Mutagenic activity of some 9-aminoalkyl acridine derivatives on S. typhimurium

Mutation Research
E Kalinowska, M Chorazy

Abstract

The mutagenic potential of 9-(3'-dimethylaminopropylamino)-acridine and of its 1-nitro and 2-nitro derivatives was investigated by using histidine-requiring mutants of Salmonella typhimurium. The 9-(3'-dimethylaminopropylamino)-acridine exhibited a weak mutagenic activity only on one of the S. typhimurium tester strains, TA1537. The 1-nitro derivative induced mutations with high frequency in strains TA1537, TA1538 and TA98, whereas the 2-nitro derivative was substantially more mutagenic than the parent compound but it was much less mutagenic than the 1-nitro derivative. Pre-mutational damages made by the 1-nitro derivative were repaired by the uvrB gene-repair system, whereas those caused by the 2-nitro derivative could not be repaired by this system. Both the 1-nitro and 2-nitro derivatives induced some mutations in the base-pair substitution strain TA100 carrying a plasmid. The frequency of the his+ mutation induced both by 1-nitro and by the 2-nitro derivatives in strain TA101 lacking a nitro reductase was lower. These results emphasize the involvement of the nitro group in the interaction of acridine derivatives with the bacterial genome.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Sep 6, 1977·Biochimica Et Biophysica Acta·J FilipskiM Chorazy
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·T LindlH Cramer
Jan 1, 1974·Annual Review of Genetics·J R Roth

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Citations

Jan 1, 1982·The International Journal of Biochemistry·B Marczyński, J Chmielowski
Sep 1, 1991·Mutation Research·L R Ferguson, W A Denny
Dec 1, 1989·Mutation Research·D G MacPhee, D Liaskou
May 1, 1995·General Pharmacology·M Gniazdowski, L Szmigiero
Jun 1, 1986·Mutation Research·J Michalska
Aug 1, 1982·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J PrivalD Popkin

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