PMID: 6990246Feb 1, 1980Paper

Mutagenic and chemical assay of extracts of airborne particulates

Mutation Research
H TokiwaY Ohnishi

Abstract

The mutagenic activity of extracts of airborne particulates was evaluated in the Salmonella system. The mutagenicity of airborne particulates was not always correlated with the content of benzo[a]pyrene (B[a]P) in the complex mixtures, especially when the samples were collected at different sites. Large-scale fractionation of extracts of airborne particulates was used to determine the content of specific mutagenic chemicals. The neutral fraction of material soluble in cyclohexane and nitromethane contained the polycyclic aromatic hydrocarbon (PAH) compounds, which accounted for 27.9% of the mutagenic activity of the whole extracts. 9 kinds of PAH compound were identified quantitatively by thin-layer chromatography. They included, per 1000 m3 of air, 12.6 microgram of benzo[e]pyrene (B]e]P), 10.7 microgram of chrysene (CHRY), 10.0 MICROGRAM OF FLUORANTHENE (FL), 6.43 microgram of benzo[ghi]perylene (B[ghi]P), 5.75 microgram of benz[a]anthracene (B[a]A), 5.33 microgram of B[a]P, 3.38 microgram of pyrene (PYR), 1.83 microgram of coronene (COR), and 1.34 microgram of perylene (PERY). Mutagenicity of the ether-soluble acidic, basic and methanol-soluble neutral fractions accounted for 10.9, 9.71 and 6.78% of the total mutagenic activ...Continue Reading

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Citations

Jul 1, 1987·Archives of Environmental Contamination and Toxicology·H Matsumoto, K Inoue
Jul 1, 1986·Archives of Environmental Contamination and Toxicology·H Matsumoto, T Kashimoto
Oct 1, 1984·Bulletin of Environmental Contamination and Toxicology·N TakedaK Hamada
Jan 1, 1991·Chemico-biological Interactions·M A BelisarioF De Lorenzo
Sep 30, 1986·Toxicology and Applied Pharmacology·J R BabsonG N Wogan
Jul 1, 1985·The Science of the Total Environment·W K de RaatS A Kooijman
Feb 1, 1985·The Science of the Total Environment·K W BrownB R Scott
May 1, 1987·The Science of the Total Environment·W K De RaatF A De Meijere
Mar 1, 1980·Mutation Research·Y OhnishiH Tokiwa
Oct 1, 1982·Mutation Research·H FukinoY Yamane
Jan 1, 1983·Mutation Research·G M AlinkJ S Boleij
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Sep 1, 1987·Mutation Research·M G KnizeJ S Felton
Aug 1, 1994·Journal of Toxicology and Environmental Health·W G PalmerS H Hoke
Jan 1, 1983·Environmental Health Perspectives·I AlfheimM Møller
Sep 4, 2015·Journal of the American Chemical Society·Rajan VyasZucai Suo
Sep 20, 2002·The Journal of Toxicological Sciences·Hiroko TsukataniNaohide Inoue
Sep 1, 1984·The Science of the Total Environment·C N Shenoy, K A Chaubal
Dec 2, 2004·Mutation Research·Larry D ClaxtonSarah H Warren
Jan 1, 1982·Microbiology and Immunology·T KinouchiY Ohnishi
Jan 1, 1983·Environmental Mutagenesis·H TokiwaR Nakagawa
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi

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