PMID: 7017397May 1, 1981Paper

Mutagenic and inhibitory properties of some new purine analogs on Salmonella typhimurium TA1530

Mutation Research
C Janion, K Myszkowska

Abstract

Mutagenic and growth-inhibitory effects of 2-amino-N6-hydroxyadenine, 2-amino-N6-methoxyadenine and 2-amino-N6-methyl-N6-hydroxyadenine were examined on S. typhimurium TA1530. All compounds showed strong mutagenic activity, and 2-amino-N6-hydroxyadenine induced mutations at a dose as low as 1 microgram/ml. 2-Amino-N6-hydroxyadenine and, to a lesser extent, 2-amino-N6-methyl-N6-hydroxyadenine (but not 2-amino-N6-methoxyadenine) exerted inhibitory effects on bacterial growth. The specificity of mutagenic action of these base analogs, as well as the target for reversion of the his- marker in TA1530, is discussed.

References

Aug 1, 1979·Mutation Research·C Janion, E Kajtaniak
Dec 15, 1977·Journal of Molecular Biology·C Coulondre, J H Miller
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW E Durston
Aug 1, 1980·Mutation Research·C Janion, B W Glickman
Mar 1, 1980·Mutation Research·E Sledziewska, C Janion

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Citations

Dec 1, 1994·Mutation Research·K NegishiH Hayatsu
Aug 1, 1991·Mutation Research·H TsuchiyamaH Hayatsu
Aug 1, 1991·Mutation Research·A Neuhäuser-Klaus
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·S W MamberS Forenza

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