Mutagenic, antioxidant and wound healing properties of Aloe vera

Journal of Ethnopharmacology
Luiza Lucy Oliveira RodriguesAna Amélia de Carvalho Melo-Cavalcante

Abstract

Aloe vera is a widely used medicinal plant for its various biological activities. This study evaluate possible mutagenic and healing effects of the aqueous extract of A. vera (AEAV) in mice and its oxidant/antioxidant potential in different proficient and deficient Saccharomyces cerevisiae strains. The AEAV was topically treated on the wounded skin surface of male albino mice at doses of 10 and 50 mg/kg for seven successive days. The control group was similarly treated with 0.9% NaCl solution. For oxidative/anti-oxidative evaluation, both proficient and deficient strains of S. cerevisiae [cytoplasmic and mitochondrial superoxide dismutase mutant (SOD: Sod1Δ and Sod2Δ), cytoplasmic catalase mutant (CAT: Cat1Δ)], two double defective mutants of Sod1 and Sod2 and Sod1 and Cat1 genes along with a wild-type strains were used. The healing property of AEAV was observed at the dose of 50 mg/kg but at the same dose it showed mutagenic and cytotoxic effects in peripheral blood. AEAV did not produce the oxidizing effect, except in the mutated CAT strain at highest concentration (50 mg/kg). The high concentration of AEAV showed mutagenicity and cytotoxicity. Beside, the healing capacity is believed to be due to its anti-oxidative defense m...Continue Reading

Citations

Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta SánchezM Pilar Gómez-Serranillos
Mar 14, 2020·BMC Complementary Medicine and Therapies·Mamokete Venolia SetshegoWilfred Otang-Mbeng
Nov 16, 2018·Applied Biochemistry and Biotechnology·Márcia Fernanda Correia Jardim PazAna Amélia de Carvalho Melo-Cavalcante
May 21, 2019·Current Dermatology Reports·Cassandra L Quave
Jun 19, 2019·Plant Foods for Human Nutrition·Marzanna HęśElżbieta Gujska
Jul 5, 2019·Current Pharmaceutical Design·Hanna SvitinaJosias Hamman
Oct 18, 2020·Tissue Engineering. Part B, Reviews·Jiaheng LiangJingan Li
Feb 12, 2021·International Journal of Molecular Sciences·Saeedeh DarziShayanti Mukherjee
Jun 25, 2021·Phytotherapy Research : PTR·Diorge Jônatas MarmittMárcia Inês Goettert
Jul 28, 2021·Tissue Engineering and Regenerative Medicine·Min Kang KimYong Woo Cho
Aug 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omid YazarluMaede Hasanpour

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