PMID: 4002244May 1, 1985

Mutagenic effect of nitrilotriacetic acid on cultured human cells

Toxicology Letters
M P Grilli, A Capucci


The mutagenic potential of nitrilotriacetic acid trisodium salt monohydrate (NTA) was evaluated on a human cell line (EUE) using selection for diphtheria toxin (DT) resistance. Cultures were treated with different doses of the chemical (2 X 10(-2)-2 X 10(-8) M) for 24 h, and cytotoxicity determined. NTA was effective in inducing diphtheria toxin-resistant (DTR) mutants, at all concentrations tested, except at 2 X 10(-6) M.


Mar 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Ved Brat, G M Williams
Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·A M FerreriG Prodi

Related Concepts

Acetic Acids
Cell Division Phases
Diphtheria Toxin
Drug Resistance
Mutagenicity Tests
Trisodium Nitrilotriacetate

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