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Mutagenic Tests Confirm That New Acetylacetonate Pt(II) Complexes Induce Apoptosis in Cancer Cells Interacting with Nongenomic Biological Targets

Metal-based Drugs

Jul 28, 2011

Sandra Angelica De PascaliFrancesco Paolo Fanizzi

Abstract

New platinum(II) complexes [PtCl(O,O'-acac)(L)] (1) and [Pt(O,O'-acac)(γ-acac)(L)] (2) (L = DMSO, a; DMS, b) containing a single chelated (O,O'-acac) (1), or one chelated and one σ-bonded (γ-acac) acetylacetonate (2) have been synthesized. The new Pt(II) complexes exhibited high in vitr...read more

Mentioned in this Paper

Biochemical Pathway
Dimethyl Sulfoxide
Complex (molecular entity)
Guanosine Monophosphate
Cytotoxicity
Tumor Cells, Malignant
Apoptosis
Observation Method - Cytotoxicity
Salmonella typhimurium
Assay
17
Paper Details
References
  • References23
  • Citations3
123
  • References23
  • Citations3
1

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Mutagenic Tests Confirm That New Acetylacetonate Pt(II) Complexes Induce Apoptosis in Cancer Cells Interacting with Nongenomic Biological Targets

Metal-based Drugs

Jul 28, 2011

Sandra Angelica De PascaliFrancesco Paolo Fanizzi

PMID: 21792272

DOI: 10.1155/2011/763436

Abstract

New platinum(II) complexes [PtCl(O,O'-acac)(L)] (1) and [Pt(O,O'-acac)(γ-acac)(L)] (2) (L = DMSO, a; DMS, b) containing a single chelated (O,O'-acac) (1), or one chelated and one σ-bonded (γ-acac) acetylacetonate (2) have been synthesized. The new Pt(II) complexes exhibited high in vitr...read more

Mentioned in this Paper

Biochemical Pathway
Dimethyl Sulfoxide
Complex (molecular entity)
Guanosine Monophosphate
Cytotoxicity
Tumor Cells, Malignant
Apoptosis
Observation Method - Cytotoxicity
Salmonella typhimurium
Assay
17

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Salmonella infections

Salmonella infections are a serious public health problem in developing countries and represent a constant concern for the food industry. Discover the latest research on Salmonella Infections here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

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A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells

Cell Death & DiseaseSeptember 14, 2013
Antonella MuscellaSanto Marsigliante
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Antitumor activity of [Pt(O,O'-acac)(γ-acac)(DMS)] in mouse xenograft model of breast cancer

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Paper Details
References
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