PMID: 6300670Apr 1, 1983Paper

Mutagenicity and genotoxicity of nitroarenes. All nitro-containing chemicals were not created equal

Mutation Research
H S Rosenkranz, R Mermelstein


The nitrated polycyclic aromatic hydrocarbons constitute a group of chemicals of environmental concern which display a broad spectrum of mutagenic, genotoxic and carcinogenic properties. Some members of the group are the most potent direct-acting bacterial mutagens while others exhibit low levels of potencies which require metabolic activation mixtures. Bacterial mutagenicity is dependent upon reduction of the nitro function. In mammalian cell systems the genetic and genotoxic effects of these nitrated chemicals include the induction of unscheduled DNA synthesis, sister-chromatid exchanges, chromosomal aberrations, gene mutations and cell transformation. The qualitative as well as quantitative expression of these effects is dependent upon the species and tissue of origin as well as culture history of the cell which in turn determine their enzymic capabilities and the conversion of these nitroarenes to ultimate mutagens and genotoxicants. In eukaryotic cells the following bioactivation pathways have been recognized: (a) reduction of the nitro moiety, (b) ring oxidation (the nature of which is influenced by the nitro function) followed by reduction of the nitro group, and (c) ring oxidation without concomitant reduction of the ni...Continue Reading


Jul 1, 1978·Cancer Letters·Y Y WangE T Wei
Oct 1, 1979·Mutation Research·B J Dean, G Hodson-Walker
Dec 1, 1978·Ecotoxicology and Environmental Safety·S CastellinoI de Carneri
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G de MurciaM Leng
Mar 1, 1977·Mutation Research·M NagaoN Ito
Apr 1, 1979·Journal of the National Cancer Institute·L A Poirier, E K Weisburger
Jun 1, 1979·Chemico-biological Interactions·J D ScribnerN K Scribner
Jul 1, 1979·Mutation Research·A Goze, R Devoret
Nov 1, 1979·Mutation Research·D E LevinE Klekowski
Jan 1, 1977·Mutation Research·J L EplerA A Hardigree
Dec 1, 1978·Toxicology and Applied Pharmacology·D E Johnson, H H Cornish
Feb 1, 1976·Mutation Research·M H Green, W J Muriel
Jul 1, 1976·Biochemical Pharmacology·H S Rosenkranz, W T Speck
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P MoreauR Devoret
Feb 1, 1975·Mutation Research·D R McCallaP L Olive
Sep 16, 1975·Biochemical and Biophysical Research Communications·H S Rosenkranz, W T Speck
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW E Durston
Feb 1, 1974·Biochemical Pharmacology·L A Poirier, J H Weisburger
Sep 22, 1965·Biochemical and Biophysical Research Communications·E Kriek
Jan 1, 1980·Cancer Chemotherapy and Pharmacology·M F BrañaA Jiménez
Mar 1, 1982·Mutation Research·H S Rosenkranz
Jun 1, 1981·Journal of Applied Toxicology : JAT·X B XuA L Burlingame
Apr 1, 1981·Journal of Applied Toxicology : JAT·T C Pederson, J S Siak
Apr 1, 1981·Journal of Applied Toxicology : JAT·T C Pederson, J S Siak
Feb 1, 1983·Mutation Research·E C McCoyR Mermelstein
Dec 1, 1980·Photochemistry and Photobiology·M Radman

❮ Previous
Next ❯


Sep 1, 1986·Cell Biology and Toxicology·E DybingS S Thorgeirsson
Jan 1, 1991·Archives of Microbiology·M A HeitkampC E Cerniglia
Jan 1, 1992·Journal of Industrial Microbiology·J B Sutherland
Oct 1, 1990·Bulletin of Environmental Contamination and Toxicology·J SuzukiS Suzuki
Jun 9, 2006·Analytical and Bioanalytical Chemistry·Barbara Zielinska, Shar Samy
Apr 29, 2008·Journal of Molecular Modeling·Vito LibrandoGaetano Tomaselli
May 1, 1984·Chemico-biological Interactions·D W BryantB E McCarry
Jan 1, 1991·Chemico-biological Interactions·L J Sammartano, D Malejka-Giganti
May 1, 1984·Mutation Research·G Klopman, H S Rosenkranz
Sep 1, 1986·Mutation Research·T SatoH Nagase
Feb 1, 1993·Mutation Research·R BecherJ A Holme
Feb 1, 1994·Mutation Research·H S Rosenkranz, G Klopman
May 1, 1987·The Science of the Total Environment·W K De RaatF A De Meijere
Sep 1, 1988·Mutation Research·B Beije, L Möller
Sep 1, 1993·Mutation Research·H TokiwaY Ohnishi

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.