PMID: 8596545Jan 1, 1996Paper

Mutagenicity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid treated with nitrite in the presence of alcohols

Mutation Research
M HigashimotoY Ohnishi

Abstract

The mutagenicity of a product produced from 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCCA), which is a component in soy sauce, after treatment with 50 mM nitrite at pH 3, 37 degrees C, for 60 min in the presence of 7.5% ethanol was much higher than that in the absence of ethanol during the nitrite treatment. The enhancement of the mutagenicity of nitrite-treated MTCCA by ethanol required simultaneous treatment of MTCCA with nitrite and ethanol. The mutagenicity of MTCCA treated with nitrite in the presence and absence of ethanol was detected in the same fractions on HPLC and was highest for Salmonella typhimurium strain YG1029 possessing elevated O-acetyltransferase activity among the several Salmonella test strains, suggesting that the same mutagen belonging to aromatic compounds was produced both in the presence and absence of ethanol. Methanol, n-propanol and isopropanol as well as ethanol were also observed to have an augmenting effect. However, the sugars glucose and sucrose had no effect. When MTCCA was treated with nitrite in the presence of commercial alcoholic beverages equivalent to 1.25-10% ethanol, Japanese 'sake' and 'shochu' were demonstrated to have a highly augmenting effect and beer, wine,...Continue Reading

References

May 1, 1983·Mutation Research·D M Maron, B N Ames
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K WakabayashiT Sugimura

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Citations

Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·M L Smith, A J Fornace
Feb 24, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M HigashimotoY Ohnishi
Aug 11, 2004·The Journal of Pharmacology and Experimental Therapeutics·Hsia-Lien LinPaul F Hollenberg
Sep 26, 1997·The Journal of Biological Chemistry·G Chu
Jun 17, 2006·Cancer Research·Randa A El-ZeinMargaret R Spitz
Apr 29, 2004·Journal of Agricultural and Food Chemistry·Tomas Herraiz, Ekaterini Papavergou
Dec 18, 2001·Journal of Agricultural and Food Chemistry·S DiemM Herderich
Sep 19, 2002·Journal of Agricultural and Food Chemistry·Sonia PiacenteCosimo Pizza
Nov 13, 2003·Journal of Agricultural and Food Chemistry·Tomas Herraiz, Juan Galisteo

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