PMID: 7035158Jan 1, 1980Paper

Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonella/mammalian-microsome test

Environmental Mutagenesis
S J Stolzenberg, C H Hine

Abstract

Short-chain, 2- and 3- carbon halogenated hydrocarbons were tested for mutagenicity for Salmonella typhimurium strain TA 100 both with and without the presence of S-9. Without exception, all brominated derivatives were more mutagenic than the chlorinated derivatives, usually by a substantial order of magnitude. 2-Fluoroethanol, the only fluorinated compound tested, showed little or no mutagenic activity up to 100 micromole per plate concentration. Two highly purified propane derivatives containing a halogen atom on each of the three carbons showed little or no direct mutagenic activity. A third trihalogenated compound with a halogen atom on each carbon atom showed some direct mutagenic activity, probably due to impurities. However, all three trihalogenated compounds were highly active mutagens following S-9 activation. The presence of a double bond in the case of 1, 2, 3-trichloropropene resulted in a higher level of direct mutagenic activity than 1, 2, 3-trichloropropane, but activation with S-9 resulted in a further increase in mutagenic activity with the former compound. On the other hand, S-9 caused a substantial decrease in mutagenic activity of most compounds containing a double bond. With the presence of an alcoholic gro...Continue Reading

References

Dec 17, 1977·Lancet·D WhortonT H Milby
Nov 1, 1978·Mutation Research·D R WadeJ E Sinsheimer
Sep 1, 1979·Mutation Research·W Lijinsky, A W Andrews
Nov 1, 1979·Journal of Toxicology and Environmental Health·S J Stolzenberg, C H Hine
Sep 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A R JonesC Murcott
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Jul 1, 1975·Bulletin of Environmental Contamination and Toxicology·H S Rosenkranz
Oct 1, 1974·Mutation Research·S RosenkranzH S Rosenkranz
Dec 1, 1973·Journal of the National Cancer Institute·W A OlsonJ H Weisburger
Feb 1, 1969·Journal of Reproduction and Fertility·G D HodgenW R Gomes
Jan 1, 1969·Life Sciences·J A Coppola
Sep 1, 1961·Toxicology and Applied Pharmacology·T R TORKELSONC H HINE

❮ Previous
Next ❯

Citations

Feb 1, 1990·Bulletin of Environmental Contamination and Toxicology·T F ConnorsJ B Cope
Jan 1, 1987·Chemico-biological Interactions·W P WatsonA S Wright
Jan 1, 1985·Mutation Research·B J DeanD H Hutson
Jul 1, 1989·Mutation Research·S Teramoto, Y Shirasu
Apr 1, 1988·Mutation Research·W von der HudeA Basler
Sep 1, 1987·Archives of Environmental Health·W N Albrecht
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Seung Jun KwackByung Mu Lee
Jan 1, 1982·Drug and Chemical Toxicology·I W DavidsonJ C Parker
Sep 26, 2014·Chemical Research in Toxicology·Suramya WaidyanathaTimothy R Fennell
Nov 3, 2010·Toxicology and Applied Pharmacology·Martin W GehlhausAbdel-Razak Kadry
Aug 6, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wan-Seob ChoDong Deuk Jang
Feb 26, 2011·Molecular Nutrition & Food Research·Nadiya BakhiyaAlfonso Lampen
Oct 1, 1994·Chemico-biological Interactions·M LågE J Søderlund
Mar 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G D Fisher, W W Kilgore
Oct 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M J Bartels, C Timchalk
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wan-Seob ChoDong Deuk Jang
May 29, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Susanne AndresAlfonso Lampen
Nov 26, 2016·Drug and Chemical Toxicology·Mine SenyildizSibel Ozden
Jun 22, 2000·Environmental and Molecular Mutagenesis·G NeurathH Marquardt
Jun 1, 1991·Journal of Applied Toxicology : JAT·B A MerrickL W Condie
Dec 1, 1980·Psychological Reports·P M PaineH S Currey
Jan 1, 1987·Environmental Mutagenesis·W von der HudeA Basler
Jan 1, 2015·Comprehensive Reviews in Food Science and Food Safety·Bai Qin Lee, Sook Mei Khor
Dec 23, 2020·International Journal of Molecular Sciences·Veronica CocchiMonia Lenzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.