PMID: 2664501Jul 1, 1989Paper

Mutagenicity of 2,6-dinitrotoluene and its metabolites, and their related compounds in Salmonella typhimurium

Mutation Research
M SayamaH Kozuka


The mutagenic activities of 2,6-dinitrotoluene (2,6-DNT) and its 6 metabolites, and their 8 related compounds were examined using Salmonella typhimurium strains TA98 and TA100 in the absence or presence of S9 mix. 2,6-DNT itself showed no mutagenicity toward either strain, but 2,6-dinitrobenzaldehyde (2,6-DNBAl), one of the metabolites of 2,6-DNT, showed the highest mutagenic activity in strain TA100. 2,6-DNBAl was a direct-acting mutagen, not requiring metabolic activation. The other compounds containing nitro groups showed weak or no mutagenic activity. This result suggests that the direct-acting mutagenicity of 2,6-DNBAl is mainly due to the aldehyde group of the 2,6-DNBAl molecule.


Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Dec 1, 1981·Mutation Research·D B CouchD J Abernethy

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Feb 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M SayamaH Kozuka
Apr 1, 1989·Photochemistry and Photobiology·T MoriJ E Trosko
May 19, 1998·Environmental and Molecular Mutagenesis·S E GeorgeL C King
Jan 1, 1995·Environmental and Molecular Mutagenesis·S E GeorgeR W Williams

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