PMID: 9541651Apr 29, 1998Paper

Mutagenicity of 6-sulfooxymethylbenzo[a]pyrene in Salmonella typhimurium and Chinese hamster V79 cells

Mutation Research
Y S ChoA S Chung

Abstract

6-Sulfooxymethylbenzo[a]pyrene (SMBP) is an ultimate and reactive form of 6-hydroxymethybenzo[a]pyrene (HMBP), which is converted into SMBP by the mediation of sulfotransferase. SMBP and HMBP with metabolic activation were mutagenic to S. typhimurium TA98 and TA100. The number of mutation per plate in strain TA98 was proportional to the concentrations of SMBP ranging from 0.2 to 1.0 nmol/plate, whereas that in strain TA100 was decreased at concentrations above 0.6 nmol/plate. The mutation frequencies by HMBP was also increased in a dose dependent manner in both strains. Furthermore, SMBP and HMBP were highly mutagenic and cytotoxic to Chinese hamster lung fibroblast (V79) cells. A dose-dependent increase in mutation frequencies at both hypoxanthine:guanine phosphoribosyltransferase (HGPRT) and sodium/potassium-ATPase (Na/K-ATPase) loci were found in V79 cells treated with SMBP and HMBP. The cytotoxicity of SMBP was increased with the increasing concentrations up to 2.5 microM, where the survival frequency and growth rate were decreased to almost 40% and 30% of the control value, respectively. The survival frequencies of V79 cells by HMBP were also decreased in a dose dependent manner up to 180 microM as similar to those of SMBP...Continue Reading

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Jun 1, 1986·Chemico-biological Interactions·E G RoganR K Saugier
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