PMID: 7035934Oct 1, 1981Paper

Mutagenicity of a series of hexacoordinate chromium (III) compounds

Mutation Research
G WarrenS J Rogers

Abstract

17 chromium(III) compounds have been tested for DNA-damaging capabilities using an E. coli differential repair assay and for mutagenicity in strains of Salmonella typhimurium. 4 of these compounds were active in both assays. Another 4 compounds were positive only in the repair assay and 9 were devoid of activity in both assays. Most of the doubly active complexes contain aromatic amine ligands like 2,2'-bipyridine and 1,10-phenanthroline. Closely related complexes of ligands derived from saturated amines are much less active. It appears that chromium(III) in the proper ligand environment can have considerable genetic toxicity and could represent one of the several possible ultimate species in a mechanism for chromium mutagenesis and carcinogenesis.

References

Feb 1, 1976·Mutation Research·M H Green, W J Muriel
Jun 1, 1975·Mutation Research·H Nishioka
Apr 1, 1976·Mutation Research·S BonattiA Abbondandolo
Feb 1, 1981·Mutation Research·G WarrenS Rogers

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Citations

Jun 30, 2000·BioFactors·D M Stearns
Apr 1, 1994·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·B GulanowskiJ Urban
Jan 1, 1992·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·K SzybaJ Urban
May 23, 2008·Archives of Toxicology·Detmar Beyersmann, Andrea Hartwig
Jan 19, 2011·Biological Trace Element Research·Halina StaniekDaria Wieczorek
Jun 1, 1988·The Science of the Total Environment·V Bianchi, A G Levis
Mar 1, 1990·Mutation Research·S De FloraP Zanacchi
Dec 1, 1982·Mutation Research·P N SchultzS Rogers
May 1, 1983·Mutation Research·V BianchiA G Levis
Dec 1, 1990·Mutation Research·I SbranaN Loprieno
Jul 1, 1990·Mutation Research·K D SugdenS J Rogers
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
May 1, 1991·Environmental Health Perspectives·E T Snow
May 1, 1987·British Journal of Industrial Medicine
Feb 9, 2010·Ecotoxicology and Environmental Safety·Davide A L VignatiBenoît J D Ferrari
Nov 24, 1999·Toxicology and Applied Pharmacology·A Flores, J M Pérez
Jan 1, 1988·Annals of the New York Academy of Sciences·T Norseth
Nov 24, 1992·Biochemistry·K D SugdenS J Rogers
Jan 1, 1993·Critical Reviews in Toxicology·M D CohenM Costa
Jan 1, 1986·Environmental Mutagenesis·M LlagosteraJ Barbé
Nov 1, 1982·Acta Pharmacologica Et Toxicologica·T NorsethS Langård
Mar 23, 2001·Alternatives to Laboratory Animals : ATLA·E RudolfM Cervinka
Jul 27, 2001·Biochemical and Biophysical Research Communications·H Y Shrivastava, B U Nair

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