PMID: 8602172Mar 26, 1996Paper

Mutagenicity of acridines in a reversion assay based on tetracycline resistance in plasmid pBR322 in Escherichia coli

Mutation Research
G R HoffmanR P Fuchs

Abstract

The mutagenicity of a series of acridine compounds was studied in an assay based on the reversion of mutations in the tetracycline-resistance gene (tet) of plasmid pBR322 in Escherichia coli. Mutations that restore the tetracycline-resistant phenotype were detected in tetracycline-sensitive strains carrying mutant plasmids. Mutations that revert by +2, +1, -1 and -2 frameshift mutations and by base-pair substitutions were used to analyze the mutagenicity of two simple acridines, two acridine mustards, and a nitroacridine. The simple acridines (9-aminoacridine and quinacrine) effectively induced -1 frameshifts and weakly induced +1 frameshifts. The acridine mustards (quinacrine mustard and ICR-191) were more potent inducers of -1 and +1 frameshifts than the simple acridines. Reactive acridines, including both the mustards and the nitroacridine Entozon, were effective inducers of -2 frameshifts but the simple acridines were not. The two classes of reactive acridines differed from one another, in that the mustards were better inducers of +1 frameshifts than Entozon, whereas Entozon was a particularly potent inducer of -2 frameshifts. None of the compounds induced +2 frameshifts, and the induction of base-pair substitutions was neg...Continue Reading

References

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Citations

Mar 26, 2003·Mutation Research·Richard Hampson, Simon M Hughes
Jul 17, 2009·PloS One·Tim C R ConibearJeremy S Webb
Feb 11, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Susimaire P MantoaniIvone Carvalho
Jan 29, 2003·Environmental and Molecular Mutagenesis·Sophie MeintièresDaniel Marzin
Feb 25, 2005·Neurosurgical Focus·Eduardo BriceñoJulio Sotelo
Jul 26, 2017·EFSA Journal·UNKNOWN European Food Safety Authority (EFSA)Marco Binaglia
Apr 1, 1997·Chemical Research in Toxicology·G R Hoffmann, R P Fuchs

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