PMID: 7035937Nov 1, 1981Paper

Mutagenicity of alkyl glycidyl ethers in three short-term assays

Mutation Research
E D ThompsonD Robinson

Abstract

The mutagenic potential of glycidol and 7 alkyl glycidyl ethers having straight alkyl chains of 2, 4, 6, 8, 10, 12, and 14 carbon atoms were examined in a battery of in vitro assays. The battery consisted of the Salmonella/mammalian microsome assay, the L5178Y mouse lymphoma assay, and unscheduled DNA synthesis using W138 cells. The mutagenic potential of the compounds ranged from strongly mutagenic to non-mutagenic; glycidol exhibited the greatest activity. All the ethers through C-4 showed a definite response whole the C-8 or higher ethers showed very weak or no responses. Dose-response curves were obtained by all 3 assays for those compounds that exhibited mutagenic activity. The sensitivity of each assay is discussed, as are the effects of the liver microsome systems used for metabolic activation.

References

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Citations

Jan 1, 1985·Mutation Research·B J DeanD H Hutson
Dec 1, 1983·Mutation Research·E B WhortonD S Folse
Nov 1, 1986·Mutation Research·D A CanterW Speck
Sep 1, 1988·Mutation Research·L B RosmanJ E Sinsheimer
Nov 1, 1990·Mutation Research·W von der HudeA Basler
Apr 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H W GardnerJ T MacGregor
Feb 26, 2011·Molecular Nutrition & Food Research·Nadiya BakhiyaAlfonso Lampen
Apr 11, 1992·Regulatory Toxicology and Pharmacology : RTP·T H GardinerW T Solomon
Oct 26, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Kunio WadaKyomu Matsumoto
Jul 13, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Jenny AasaMargareta Törnqvist
Sep 27, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Bernhard RainerManfred Tacker
Jan 1, 1983·Environmental Mutagenesis·W J CoppingerE D Thompson
Jan 15, 2020·The Journal of Toxicological Sciences·Michiharu MatsumotoJun Kanno

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