PMID: 11342245May 9, 2001Paper

Mutagenicity of bisphenol A and its suppression by interferon-alpha in human RSa cells

Mutation Research
S TakahashiN Suzuki

Abstract

Bisphenol A is used as a monomer in the production of polycarbonate plastic products. The widespread use of bisphenol A has raised concerns about its effects in humans. Since there is little information on the mutagenic potential of the chemical, the mutagenicity of bisphenol A was tested using human RSa cells, which has been utilized for identification of novel mutagens. In genomic DNA from cells treated with bisphenol A at concentrations ranging from 1x10(-7) to 1x10(-5)M, base substitution mutations at K-ras codon 12 were detected using PCR and differential dot-blot hybridization with mutant probes. Mutations were also detected using the method of peptide nucleic acid (PNA)-mediated PCR clamping. The latter method enabled us to detect the mutation in bisphenol A-treated cells at a dose (1x10(-8)M) equivalent to that typically found in the environment. Induction of ouabain-resistant (Oua(R)) phenotypic mutation was also found in cells treated with 1x10(-7) and 1x10(-5)M of bisphenol A. The induction of K-ras codon 12 mutations and Oua(R) mutations was suppressed by pretreating RSa cells with human interferon (HuIFN)-alpha prior to bisphenol A treatment. The cells treated with bisphenol A at the concentration of 1x10(-6)M elic...Continue Reading

References

Nov 1, 1988·Mutation Research·N Suzuki, H Suzuki
Apr 1, 1985·Mutation Research·H SuzukiK Hiraga
Aug 1, 1995·Mutation Research·H Suzuki, N Suzuki
Jan 1, 1995·Environmental and Molecular Mutagenesis·A Atkinson, D Roy
Jan 16, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O PelkonenH Raunio
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C A JonesR W Tennant

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Citations

May 17, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·Janine E Polifka, J M Friedman
Oct 24, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Timothy J SchraderW Cherry
Apr 10, 2007·Applied Biochemistry and Biotechnology·Hayato YamanakaKiyofumi Sakai
May 18, 2013·Applied Microbiology and Biotechnology·Weiwei ZhangLingxin Chen
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Jannette WoberGünter Vollmer
Dec 1, 2001·Biochemical and Biophysical Research Communications·T SugitaN Suzuki
Mar 10, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kazuko KitaNobuo Suzuki
Oct 5, 2007·Mutation Research·Sumiko TayamaKuniaki Tayama
Aug 21, 2007·Reproductive Toxicology·Ruth A KeriGail S Prins
Feb 19, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yasuko MutouRensuke Goto
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Justin G Teeguarden, Sesha Hanson-Drury
Jun 14, 2014·Frontiers in Public Health·Hueiwang Anna Jeng
Jan 3, 2012·The Science of the Total Environment·C Eliana GattulloElisabetta Loffredo
Jan 24, 2016·Reproductive Toxicology·Keith M GoldsteinThomas K Baker
Jan 24, 2017·Molecular and Cellular Endocrinology·Danila CuomoConcetta Ambrosino
Jul 10, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert E ChapinSusan R Woskie
Sep 8, 2011·Bioscience, Biotechnology, and Biochemistry·Xia JiangNobuo Suzuki
Jan 31, 2003·Molecular Carcinogenesis·Miquel PortaManuel Jariod
Mar 8, 2003·The Journal of Laboratory and Clinical Medicine·Ritsuko HasegawaNobuo Suzuki
Mar 23, 2010·Journal of Hazardous Materials·S SaiyoodD Inthorn

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